Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23288
Abstract: Ionizing radiation (IR) is commonly used to treat central nervous system (CNS) cancers and metastases. While IR promotes remission, frequent side effects including impaired cognition and white matter loss occur following treatment. Fractionation is used… read more here.
Keywords: fractionation; radiation; sensitivity; oligodendrocyte progenitor ... See more keywords
Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24014
Abstract: Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) causes a rare and debilitating form of X‐linked psychomotor disability known as Allan Herndon Dudley syndrome (AHDS). One of the most prominent pathophysiological… read more here.
Keywords: mct8; across brain; oligodendrocyte progenitor; maturation ... See more keywords
A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
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DOI: 10.1002/glia.24189
Abstract: Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are… read more here.
Keywords: diffuse midline; mouse; origin dependent; midline glioma ... See more keywords
Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24780
Abstract: Axonal damage and the subsequent interruption of intact neuronal pathways in the spinal cord are largely responsible for the loss of motor function after injury. Further exacerbating this loss is the demyelination of neighboring uninjured… read more here.
Keywords: chondroitin sulfate; oligodendrocyte progenitor; sulfate proteoglycans; neurotrophic factor ... See more keywords
Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0563-4
Abstract: Recently our group used oligodendrocyte progenitor cells (OPCs) as appropriate model cells to pinpoint the mechanism of the progress of neurodegenerative disorders. In the present study, we focused on the therapeutic role of osteopontin (OPN),… read more here.
Keywords: progenitor cells; osteopontin; apoptosis; h2o2 ... See more keywords
The endocannabinoid 2‐arachidonoylglycerol regulates oligodendrocyte progenitor cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.006
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT While the endocannabinoid 2‐arachidonoylglycerol (2‐AG) is thought to enhance the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) in vitro, less is known about how endogenous 2‐AG may… read more here.
Keywords: migration; oligodendrocyte progenitor; cb1 cb2; endocannabinoid arachidonoylglycerol ... See more keywords
Oligodendrocyte progenitor cell fate and function in development and disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2021.05.003
Abstract: Differentiation of oligodendrocyte progenitor cells (OPCs) into myelination-capable mature oligodendrocytes is essential for proper function of the central nervous system. OPCs are tissue-resident stem cells that populate all regions of the central nervous system and… read more here.
Keywords: fate function; oligodendrocyte progenitor; function; cell ... See more keywords
Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2022.102205
Abstract: The key pathology of multiple sclerosis (MS) comprises demyelination, axonal damage, and neuronal loss, and when MS develops into the progressive phase it is essentially untreatable. Identifying new targets in both axons and oligodendrocyte progenitor… read more here.
Keywords: oligodendrocyte progenitor; progenitor cells; demyelinated lesion; metabolism ... See more keywords
Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121623
Abstract: Impairment of oligodendrocyte progenitor cell (OPC) differentiation into oligodendrocytes and chronic inflammation are key determinants of poor remyelination observed in diseases such as multiple sclerosis. For many pro-myelinating molecules, the therapeutic potential is hindered by… read more here.
Keywords: pdgfr; oligodendrocyte progenitor; pdgfr antibody; anti pdgfr ... See more keywords
Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.05.016
Abstract: There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte progenitor cells (OPCs),… read more here.
Keywords: progenitor cells; disruption; age; alzheimer disease ... See more keywords
Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10095-1
Abstract: Endogenous remyelination in demyelinating diseases such as multiple sclerosis is contingent upon the successful differentiation of oligodendrocyte progenitor cells (OPCs). Signaling via the Gαq-coupled muscarinic receptor (M1/3R) inhibits human OPC differentiation and impairs endogenous remyelination… read more here.
Keywords: oligodendrocyte progenitor; differentiation; oscillatory calcium; calcium release ... See more keywords