Oligodeoxynucleotides Modified with 2'-O-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions.
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DOI: 10.1021/acs.bioconjchem.1c00575
Abstract: We used native chemical ligation (NCL) to synthesize a 2'-O-{N-[N-(S-tert-butylthiocysteinyl)aminobutyl]carbamoylethyl} (CysBCE) ribothymidine-derived oligonucleotide to expand the variety of peptide conjugation sites, allowing the incorporation of peptides at the 2'-hydroxy group when the oligonucleotide forms a… read more here.
Keywords: chemical ligation; cysteinylaminobutyl carbamoylethylribothymidine; oligodeoxynucleotides modified; native chemical ... See more keywords