Comparison of the unfolding and oligomerization of human prion protein under acidic and neutral environments by molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2018.07.014
Abstract: Abstract Aggregation of the misfolded scrapie prion protein (PrPSc) is known to cause neurodegenerative diseases. In this paper, we have investigated the stability of PrPC by combining coarse-grained model and all-atom molecular simulations. Our results… read more here.
Keywords: oligomerization human; prion; comparison unfolding; unfolding oligomerization ... See more keywords
Oligomerization of Human Cystatin C—An Amyloidogenic Protein: An Analysis of Small Oligomeric Subspecies
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DOI: 10.3390/ijms232113441
Abstract: Human cystatin C (HCC), an amyloidogenic protein, forms dimers and higher oligomers (trimers, tetramers and donut like large oligomers) via a domain-swapping mechanism. The aim of this study was the characterization of the HCC oligomeric… read more here.
Keywords: oligomerization human; hcc; amyloidogenic protein; human cystatin ... See more keywords