Chemical Biology Approaches toward Precise Structure Control of IgG‐Based Antibody‐Oligonucleotide Conjugates
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DOI: 10.1002/cbic.202300077
Abstract: Antibody‐oligonucleotide conjugates (AOCs) are important tools for drug development and biochemical analysis. However, the structural heterogeneity of AOCs synthesized through conventional coupling methods raises reproducibility and safety concerns in clinical trials. To address these issues,… read more here.
Keywords: chemical biology; control; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords
Non-specific interactions of antibody-oligonucleotide conjugates with living cells
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DOI: 10.1038/s41598-021-85352-w
Abstract: Antibody-Oligonucleotide Conjugates (AOCs) represent an emerging class of functionalized antibodies that have already been used in a wide variety of applications. While the impact of dye and drug conjugation on antibodies’ ability to bind their… read more here.
Keywords: oligonucleotide conjugates; non specific; living cells; specific interactions ... See more keywords
Generation of oligonucleotide conjugates via one-pot diselenide-selenoester ligation–deselenization/alkylation
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DOI: 10.1039/d1sc04937b
Abstract: A breadth of strategies are needed to efficiently modify oligonucleotides with peptides or lipids to capitalize on their therapeutic and diagnostic potential, including the modulation of in vivo chemical stability and for applications in cell-targeting… read more here.
Keywords: oligonucleotide conjugates; deselenization; diselenide; diselenide selenoester ... See more keywords
Recent preclinical and clinical advances in oligonucleotide conjugates
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DOI: 10.1080/17425247.2018.1473375
Abstract: ABSTRACT Introduction: Oligonucleotide therapeutics have the potential to change the way disease is treated due to their ability to modulate gene expression of any therapeutic target in a highly specific and potent manner. Unfortunately, this… read more here.
Keywords: clinical advances; oligonucleotide conjugates; advances oligonucleotide; oligonucleotide therapeutics ... See more keywords
Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs).
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad415
Abstract: Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties remained unknown in higher species. We developed antibody-oligonucleotide conjugates (AOCs) towards mice or monkeys utilizing anti-TfR1… read more here.
Keywords: muscle; conjugates aocs; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords
Novel Lipid-Oligonucleotide Conjugates Containing Long-Chain Sulfonyl Phosphoramidate Groups: Synthesis and Biological Properties
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DOI: 10.3390/app11031174
Abstract: New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3′ or 5′-end were synthesized and characterized. Low cytotoxicity of the conjugates and their ability… read more here.
Keywords: novel lipid; sulfonyl phosphoramidate; oligonucleotide conjugates; phosphoramidate ... See more keywords
Synthesis of Protein-Oligonucleotide Conjugates
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DOI: 10.3390/biom12101523
Abstract: Nucleic acids and proteins form two of the key classes of functional biomolecules. Through the ability to access specific protein-oligonucleotide conjugates, a broader range of functional molecules becomes accessible which leverages both the programmability and… read more here.
Keywords: synthesis protein; oligonucleotide conjugates; protein oligonucleotide;
Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates
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DOI: 10.3390/pharmaceutics15010248
Abstract: Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the… read more here.
Keywords: application; ligatable oligonucleotide; synthesis; nucleoside phosphoramidite ... See more keywords
Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies
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DOI: 10.3390/pharmaceutics15020320
Abstract: Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up into… read more here.
Keywords: purposes simple; peptide oligonucleotide; lipid peptide; conjugates therapeutic ... See more keywords
Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles
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DOI: 10.3390/pharmaceutics15061643
Abstract: Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is… read more here.
Keywords: cationic nanoparticles; targeted anticancer; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords