Antisense Oligonucleotide Targeting of 3'-UTR of mRNA for Expression Knockdown.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8651-4_6
Abstract: With the recent conditional approval of an antisense oligonucleotide (AON) that restores the reading frame of DMD transcript in a subset of Duchenne muscular dystrophy patients, it has been established that AONs sharing similar chemistry… read more here.
Keywords: targeting utr; utr mrna; oligonucleotide targeting; expression ... See more keywords
AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval
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DOI: 10.1111/bcp.15425
Abstract: AZD8233 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) antisense oligonucleotide under development for treatment of hypercholesterolaemia. A prespecified concentrationâQT analysis was performed based on data from a single ascending dose study that was prospectively… read more here.
Keywords: antisense oligonucleotide; targeting pcsk9; azd8233 antisense; azd8233 ... See more keywords