Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-1966-2
Abstract: Immunotherapies emerged as an alternative for cancer treatment, yet their clinical efficacies are still limited, especially in case of solid tumors. Myeloid immune cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), are often hijacked… read more here.
Keywords: myeloid cells; oligonucleotide therapeutics; stat3; cancer ... See more keywords
Intracellular Absolute Quantification of Oligonucleotide Therapeutics by NanoSIMS.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02111
Abstract: Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of a variety of diseases. Therefore, a better understanding of cellular delivery, uptake, and trafficking mechanisms of ASOs is highly important for early-stage drug discovery.… read more here.
Keywords: quantification oligonucleotide; quantification; intracellular absolute; aso ... See more keywords
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00830
Abstract: A major obstacle in the development of effective oligonucleotide therapeutics is a lack of understanding about their cytosolic and nuclear penetration. To address this problem, we have applied the chloroalkane penetration assay (CAPA) to oligonucleotide… read more here.
Keywords: quantitative measurement; penetration; nuclear penetration; cytosolic nuclear ... See more keywords
Recent preclinical and clinical advances in oligonucleotide conjugates
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2018.1473375
Abstract: ABSTRACT Introduction: Oligonucleotide therapeutics have the potential to change the way disease is treated due to their ability to modulate gene expression of any therapeutic target in a highly specific and potent manner. Unfortunately, this… read more here.
Keywords: clinical advances; oligonucleotide conjugates; advances oligonucleotide; oligonucleotide therapeutics ... See more keywords
Hyaluronan-based delivery of therapeutic oligonucleotides for treatment of human diseases
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2019.1617693
Abstract: ABSTRACT Introduction: Oligonucleotide therapeutics such as antisense oligonucleotides and siRNA requires chemical modifications and nano-sized carriers to circumvent stability problems in vivo, to reach target tissues, and to overcome tissue and cellular barriers. Hyaluronic acid… read more here.
Keywords: delivery; oligonucleotide therapeutics; based delivery; hyaluronan based ... See more keywords
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad023
Abstract: Abstract Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic tissues remains… read more here.
Keywords: fusion; lysosomal fusion; endocytic recycling; activity ... See more keywords
Chemistry, structure and function of approved oligonucleotide therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad067
Abstract: Abstract Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), RNA interference (RNAi) and an RNA… read more here.
Keywords: function approved; chemistry structure; structure function; chemistry ... See more keywords
Antitumoral RNA‐targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15461
Abstract: Oligonucleotide therapeutics, drugs consisting of 10–50 nucleotide‐long single‐ or double‐stranded DNA or RNA molecules that can bind to specific DNA or RNA sequences or proteins, include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), microRNAs (miRNAs),… read more here.
Keywords: antitumoral rna; third pillar; rna; targeted oligonucleotide ... See more keywords
Future directions for medicinal chemistry in the field of oligonucleotide therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079511.122
Abstract: In the last decade, the field of oligonucleotide therapeutics has matured, with the regulatory approval of several single-stranded and double-stranded RNA drugs. In this Perspective, I discuss enabling developments and likely future directions in the… read more here.
Keywords: chemistry; field oligonucleotide; future directions; directions medicinal ... See more keywords
Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.941528
Abstract: The advent of stem cell-derived cerebral organoids has already advanced our understanding of disease mechanisms in neurological diseases. Despite this, many remain without effective treatments, resulting in significant personal and societal health burden. Antisense oligonucleotides… read more here.
Keywords: antisense oligonucleotide; disease; cerebral organoids; oligonucleotide therapeutics ... See more keywords
Making Sense of Antisense Oligonucleotide Therapeutics Targeting Bcl-2
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010097
Abstract: The B-cell lymphoma 2 (Bcl-2) family, comprised of pro- and anti-apoptotic proteins, regulates the delicate balance between programmed cell death and cell survival. The Bcl-2 family is essential in the maintenance of tissue homeostasis, but… read more here.
Keywords: antisense oligonucleotide; sense antisense; making sense; oligonucleotide therapeutics ... See more keywords