The chemical evolution of oligonucleotide therapies of clinical utility
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3765
Abstract: After nearly 40 years of development, oligonucleotide therapeutics are nearing meaningful clinical productivity. One of the key advantages of oligonucleotide drugs is that their delivery and potency are derived primarily from the chemical structure of… read more here.
Keywords: clinical utility; evolution oligonucleotide; chemical evolution; oligonucleotide therapies ... See more keywords
Oligonucleotide therapies for disorders of the nervous system
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3784
Abstract: Oligonucleotide therapies are currently experiencing a resurgence driven by advances in backbone chemistry and discoveries of novel therapeutic pathways that can be uniquely and efficiently modulated by the oligonucleotide drugs. A quarter of a century… read more here.
Keywords: nervous system; therapies disorders; oligonucleotide therapies; brain ... See more keywords