Post-synthetic modification of oligonucleotides containing 5-mono- and 5-di-fluoromethyluridines
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DOI: 10.1016/j.tet.2020.131769
Abstract: Abstract Synthesis of 2ʹ-deoxy-5-fluoromethyluridine (dUCH2F) and 2ʹ-deoxy-5-difluoromethyluridine (dUCHF2) phosphoramidites was achieved. The obtained phosphoramidites were efficiently incorporated into oligonucleotides (ONs), and their post-synthetic modification was examined. In the case of dUCH2F-containing ONs, substitution of the… read more here.
Keywords: post synthetic; modification oligonucleotides; synthetic modification; containing mono ... See more keywords
Oligonucleotides Containing 1-Aminomethyl or 1-Mercaptomethyl-2-deoxy-d-ribofuranoses: Synthesis, Purification, Characterization, and Conjugation with Fluorophores and Lipids.
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DOI: 10.1021/acs.bioconjchem.0c00717
Abstract: Oligonucleotide conjugates are widely used as therapeutic drugs, gene analysis, and diagnostic tools. A critical step in the biologically relevant oligonucleotide conjugates is the design and synthesis of functional molecules that connect oligonucleotide with ligands.… read more here.
Keywords: aminomethyl mercaptomethyl; deoxy ribofuranoses; containing aminomethyl; mercaptomethyl deoxy ... See more keywords
The oligonucleotides containing N7-regioisomer of guanosine: influence on thermodynamic properties and structure of RNA duplexes
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DOI: 10.1261/rna.080106.124
Abstract: During the chemical synthesis of the purine riboside, N7-regioisomer is kinetically formed, whereas N9-regioisomer is a thermodynamically formed product. We have studied the effect of substituting N9-regioisomer of guanosine with its N7-regioisomer (N7-guanosine, 7G) at… read more here.
Keywords: regioisomer guanosine; containing regioisomer; regioisomer; oligonucleotides containing ... See more keywords