Articles with "olz" as a keyword



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Bioequivalence of Olanzapine Given in Combination With Samidorphan as a Bilayer Tablet (ALKS 3831) Compared With Olanzapine‐Alone Tablets: Results From a Randomized, Crossover Relative Bioavailability Study

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Published in 2019 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.601

Abstract: The objective of this study was to evaluate the relative bioavailability of olanzapine in 3 olanzapine‐containing tablet formulations. ALKS 3831 is a fixed‐dose combination of olanzapine (OLZ, an atypical antipsychotic) and samidorphan (SAM, a μ‐opioid… read more here.

Keywords: bioequivalence; alks 3831; olz; olanzapine ... See more keywords
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Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies

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Published in 2018 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-018-1213-y

Abstract: Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n.) route. The… read more here.

Keywords: loaded nanostructured; olz mnlc; delivery; olz ... See more keywords
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Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends

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Published in 2022 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics14081535

Abstract: The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the… read more here.

Keywords: amorphous olanzapine; crystalline olz; amorphous amorphous; amorphous olz ... See more keywords