A randomized, double-blind, placebo-controlled proof of concept study to evaluate samidorphan in the prevention of olanzapine-induced weight gain in healthy volunteers
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DOI: 10.1016/j.schres.2017.10.014
Abstract: Antipsychotic medications are associated with weight gain and adverse metabolic effects that complicate the treatment and management of schizophrenia. Olanzapine (OLZ) in particular is associated with significant weight gain and adverse metabolic effects. The present… read more here.
Keywords: randomized double; gain; proof concept; olz sam ... See more keywords
A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia: Results from the ENLIGHTEN-2 long-term extension
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DOI: 10.1016/j.schres.2021.04.009
Abstract: AIM A combination of olanzapine and samidorphan (OLZ/SAM) is in development for the treatment of patients with schizophrenia or bipolar I disorder and is intended to provide the efficacy of olanzapine while mitigating olanzapine-associated weight… read more here.
Keywords: week; patients schizophrenia; study; olz sam ... See more keywords
A Structured Benefit-Risk Assessment to Evaluate a Combination of Olanzapine and Samidorphan for the Treatment of Schizophrenia and Bipolar I Disorder
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DOI: 10.1017/s1092852922000311
Abstract: Abstract Background A combination of olanzapine and samidorphan (OLZ/SAM) that provides the efficacy of olanzapine while mitigating weight gain was recently approved by the FDA for the treatment of schizophrenia and bipolar I disorder. To… read more here.
Keywords: olanzapine samidorphan; benefit risk; risk; olz sam ... See more keywords
Olanzapine-samidorphan combination tablets for the treatment of schizophrenia and bipolar I disorder - what is it, and will it be used?
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DOI: 10.1080/14737175.2022.2060742
Abstract: ABSTRACT Introduction Although olanzapine remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there are significant tolerability concerns related to its weight and metabolic profile. Olanzapine-samidorphan combination tablets (OLZ/SAM), branded as… read more here.
Keywords: olanzapine samidorphan; olz sam; olanzapine; samidorphan combination ... See more keywords
Olanzapine/Samidorphan: A New Option for the Treatment of Adults With Schizophrenia or Bipolar I Disorder
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DOI: 10.1177/87551225221114281
Abstract: Objective: To review the pharmacology, pharmacokinetics, and efficacy and safety data of a combination of olanzapine and samidorphan (OLZ/SAM) for the treatment of schizophrenia and bipolar I disorder, which mitigates the possible unwanted side effects… read more here.
Keywords: olanzapine samidorphan; olz sam; schizophrenia bipolar; bipolar disorder ... See more keywords
An Evidence-Based Review of OLZ/SAM for Treatment of Adults with Schizophrenia or Bipolar I Disorder [Corrigendum]
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DOI: 10.2147/ndt.s340597
Abstract: [This corrects the article DOI: 10.2147/NDT.S313840.]. read more here.
Keywords: treatment; sam treatment; based review; olz sam ... See more keywords