Development and Optimization of Osimertinib-loaded Biodegradable Polymeric Nanoparticles Enhance In-vitro Cytotoxicity in Mutant EGFR NSCLC Cell Models and In-vivo Tumor Reduction in H1975 Xenograft Mice Models
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02314-9
Abstract: Osimertinib (OMB), a third-generation EGFR inhibitor, specifically and irreversibly inhibits EGFRT790M mutant form. Nevertheless, its clinical use is limited due to poor solubility, low absorption, and oral bioavailability. To overcome the low therapeutic capabilities of… read more here.
Keywords: omb chs; omb; mutant egfr; h1975 ... See more keywords
Striatal Transcriptome Reveals Differences Between Cognitively Impaired and Unimpaired Aged Male Rats
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DOI: 10.3389/fnagi.2020.611572
Abstract: Cognitive processes require striatal activity. The underlying molecular mechanisms are widely unknown. For this reason the striatal transcriptome of young (YM), aged cognitively impaired (OMB), and unimpaired (OMG) male rats was analyzed. The global comparison… read more here.
Keywords: omb; male rats; cognitively impaired; regulated genes ... See more keywords