Multi‐omics analysis reveals multiple mechanisms causing Prader–Willi like syndrome in a family with a X;15 translocation
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24440
Abstract: Prader–Willi syndrome (PWS; MIM# 176270) is a neurodevelopmental disorder caused by the loss of expression of paternally imprinted genes within the PWS region located on 15q11.2. It is usually caused by either maternal uniparental disomy… read more here.
Keywords: translocation; multi omics; prader willi; omics analysis ... See more keywords
Multi-Omics Analysis Reveals OBSCN as a Key Modulator of Tumor Microenvironment, Microbial Signatures and Clinical Outcomes in Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.70186
Abstract: Emerging evidence suggests that OBSCN, a giant cytoskeletal protein gene, plays multifaceted roles in cancer progression, yet its impact on gastric cancer (GC) remains poorly understood. Through integrative analysis of multi‐omics datasets, we observe a… read more here.
Keywords: cancer; multi omics; gastric cancer; tumor ... See more keywords
Omics analysis of acetic acid tolerance in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Microbiology and Biotechnology"
DOI: 10.1007/s11274-017-2259-9
Abstract: Acetic acid is an inhibitor in industrial processes such as wine making and bioethanol production from cellulosic hydrolysate. It causes energy depletion, inhibition of metabolic enzyme activity, growth arrest and ethanol productivity losses in Saccharomyces… read more here.
Keywords: saccharomyces cerevisiae; omics analysis; acid tolerance; acetic acid ... See more keywords
Omics analysis of holoproteins and modified proteins of quail egg.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.126983
Abstract: Confirmed to be a new type of food resource, quail egg can provide humans with high-quality protein and offer various nutrients that can promote growth and development. Post-translational modification of proteins can regulate their molecular… read more here.
Keywords: egg; modified proteins; omics analysis; quail egg ... See more keywords
Multi-omics analysis provides insights into genetic architecture of flavonoid metabolites in Populus
Sign Up to like & getrecommendations! Published in 2021 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2021.113612
Abstract: Abstract Flavonoids are widely distributed secondary metabolites as well as a major class of chemical defenses in response to light intensity, temperature, and other external factors. However, systematic investigation on the genetic basis of flavonoids… read more here.
Keywords: omics analysis; insights genetic; analysis provides; geographical regions ... See more keywords
A Unique Energy-Saving Strategy during Hibernation Revealed by Multi-Omics Analysis in the Chinese Alligator
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101202
Abstract: Summary Many ectotherms hibernate in face of the harsh winter conditions to improve their survival rate. However, the molecular mechanism underlying this process remains unclear. Here, we explored the hibernation mechanism of Chinese alligator using… read more here.
Keywords: multi omics; hibernation; unique energy; omics analysis ... See more keywords
Efficient Sample Preparation System for Multi-Omics Analysis via Single Cell Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05728
Abstract: Mass spectrometry (MS) has become a powerful tool for metabolome, lipidome, and proteome analyses. The efficient analysis of multi-omics in single cells, however, is still challenging in the manipulation of single cells and lack of… read more here.
Keywords: cell; multi omics; mass spectrometry; single cell ... See more keywords
Simultaneous Polar Metabolite and N-Glycan Extraction Workflow for Joint-Omics Analysis: A Synergistic Approach for Novel Insights into Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00676
Abstract: Bioinformatics and machine learning tools have made it possible to integrate data across different -omics platforms for novel multiomic insights into diseases. To synergistically process -omics data in an integrative manner, analyte extractions for each… read more here.
Keywords: extraction; omics analysis; joint omics; simultaneous polar ... See more keywords
Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55869-2
Abstract: Spaceflight has several detrimental effects on the physiology of astronauts, many of which are recapitulated in rodent models. Mouse studies performed on the Space Shuttle showed disruption of lipid metabolism in liver. However, given that… read more here.
Keywords: analysis multiple; space; multi omics; liver ... See more keywords
Field multi-omics analysis reveals a close association between bacterial communities and mineral properties in the soybean rhizosphere
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87384-8
Abstract: The plant root-associated environments such as the rhizosphere, rhizoplane, and endosphere are different from the outer soil region (bulk soil). They establish characteristic conditions including microbiota, metabolites, and minerals, and they can directly affect plant… read more here.
Keywords: multi omics; field; bacterial communities; omics analysis ... See more keywords
Multi-omics analysis reveals the genetic aging landscape of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-82470-z
Abstract: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease. Despite numerous studies, specific age-related factors remain unidentified. This study employed a multi-omics approach to investigate the link between PD and… read more here.
Keywords: disease; multi omics; analysis; parkinson disease ... See more keywords