Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2214-z
Abstract: Bosentan is well known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic, and metabolomic levels. For this purpose,… read more here.
Keywords: induced bosentan; hepatoma; omics based; human hepatoma ... See more keywords
Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
Sign Up to like & getrecommendations! Published in 2020 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101121
Abstract: A plethora of genetic and molecular mechanisms have been implicated in the pathophysiology of the heterogeneous and multifactorial amyotrophic lateral sclerosis (ALS) disease, and hence the conventional "one target-one drug" paradigm has failed so far… read more here.
Keywords: omics based; therapeutic targets; based exploration; factors histamine ... See more keywords
An omics-based framework for assessing the health risk of antimicrobial resistance genes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25096-3
Abstract: Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs pose serious threats to public health, highlighting the importance of identifying those that are high-risk. Here, we developed an ‘omics-based’ framework to evaluate… read more here.
Keywords: risk; omics based; framework; health ... See more keywords
State of omics-based microbial diagnostics of CRC
Sign Up to like & getrecommendations! Published in 2025 at "Gut Microbes"
DOI: 10.1080/19490976.2025.2526132
Abstract: ABSTRACT Colorectal cancer (CRC) remains a major burden of cancer-related morbidity and mortality globally, especially when detected at later stages. Early detection through improved and more accessible diagnostics is critical for reducing the severity of… read more here.
Keywords: microbial diagnostics; omics based; crc; gut microbiome ... See more keywords
Calcific aortic stenosis: omics-based target discovery and therapy development.
Sign Up to like & getrecommendations! Published in 2024 at "European heart journal"
DOI: 10.1093/eurheartj/ehae829
Abstract: Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those over age 65. Those who develop symptomatic severe AS have an average… read more here.
Keywords: omics based; stenosis omics; calcific aortic; discovery ... See more keywords
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Sign Up to like & getrecommendations! Published in 2021 at "Biological Reviews"
DOI: 10.1111/brv.12691
Abstract: Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for… read more here.
Keywords: adhesion aquatic; omics based; aquatic invertebrates; based molecular ... See more keywords
Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0432-8
Abstract: BackgroundThe completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have contributed immensely to… read more here.
Keywords: medicine; omics based; oral pathology; pathology ... See more keywords
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0673-3
Abstract: A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method… read more here.
Keywords: omics based; identify novel; drug; methods identify ... See more keywords
Liquid biopsies for omics-based analysis in sentinel mussels
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223525
Abstract: Liquid biopsy of plasma is a simple and non-invasive technology that holds great promise in biomedical research. It is based on the analysis of nucleic acid-based biomarkers with predictive potential. In the present work, we… read more here.
Keywords: liquid biopsies; omics based; analysis; based analysis ... See more keywords
Steroid Profiling for Adrenocortical Disorders: A Pathway for Omics-Based Diagnostics.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical chemistry"
DOI: 10.1373/clinchem.2017.281048
Abstract: During the past 15 years, a considerable investment of effort and funds has been directed to the use of omics-based technologies for biomarker identification and development. The outcome in terms of laboratory tests applicable to… read more here.
Keywords: steroid profiling; profiling adrenocortical; omics based; mass spectrometry ... See more keywords
Artificial intelligence and omics-based autoantibody profiling in dementia
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1537659
Abstract: Introduction Dementia is a neurodegenerative syndrome marked by the accumulation of disease-specific proteins and immune dysregulation, including autoimmune mechanisms involving autoantibodies. Current diagnostic methods are often invasive, time-consuming, or costly. Methods This study explores the… read more here.
Keywords: dementia; autoantibody; artificial intelligence; omics based ... See more keywords