Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2214-z
Abstract: Bosentan is well known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic, and metabolomic levels. For this purpose,… read more here.
Keywords: induced bosentan; hepatoma; omics based; human hepatoma ... See more keywords
Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
Sign Up to like & getrecommendations! Published in 2020 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101121
Abstract: A plethora of genetic and molecular mechanisms have been implicated in the pathophysiology of the heterogeneous and multifactorial amyotrophic lateral sclerosis (ALS) disease, and hence the conventional "one target-one drug" paradigm has failed so far… read more here.
Keywords: omics based; therapeutic targets; based exploration; factors histamine ... See more keywords
An omics-based framework for assessing the health risk of antimicrobial resistance genes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25096-3
Abstract: Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs pose serious threats to public health, highlighting the importance of identifying those that are high-risk. Here, we developed an ‘omics-based’ framework to evaluate… read more here.
Keywords: risk; omics based; framework; health ... See more keywords
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Sign Up to like & getrecommendations! Published in 2021 at "Biological Reviews"
DOI: 10.1111/brv.12691
Abstract: Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for… read more here.
Keywords: adhesion aquatic; omics based; aquatic invertebrates; based molecular ... See more keywords
Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0432-8
Abstract: BackgroundThe completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have contributed immensely to… read more here.
Keywords: medicine; omics based; oral pathology; pathology ... See more keywords
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0673-3
Abstract: A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method… read more here.
Keywords: omics based; identify novel; drug; methods identify ... See more keywords
Liquid biopsies for omics-based analysis in sentinel mussels
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223525
Abstract: Liquid biopsy of plasma is a simple and non-invasive technology that holds great promise in biomedical research. It is based on the analysis of nucleic acid-based biomarkers with predictive potential. In the present work, we… read more here.
Keywords: liquid biopsies; omics based; analysis; based analysis ... See more keywords
Steroid Profiling for Adrenocortical Disorders: A Pathway for Omics-Based Diagnostics.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical chemistry"
DOI: 10.1373/clinchem.2017.281048
Abstract: During the past 15 years, a considerable investment of effort and funds has been directed to the use of omics-based technologies for biomarker identification and development. The outcome in terms of laboratory tests applicable to… read more here.
Keywords: steroid profiling; profiling adrenocortical; omics based; mass spectrometry ... See more keywords
Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10101377
Abstract: Cholangiocarcinoma (CCA) has been identified as a highly malignant cancer that can be transformed from epithelial cells of the bile duct, including intrahepatic, perihilar and extrahepatic. High-resolution imaging tools (abdominal ultrasound, computed tomography and percutaneous… read more here.
Keywords: status; based platforms; omics based; current status ... See more keywords
An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11020155
Abstract: Substantial alterations at the multi-omics level of pancreatic cancer (PC) impede the possibility to diagnose and treat patients in early stages. Herein, we conducted an integrative omics-based translational analysis, utilizing next-generation sequencing, transcriptome meta-analysis, and… read more here.
Keywords: omics based; validation; based translational; pancreatic cancer ... See more keywords
Multi-Omics-Based Discovery of Plant Signaling Molecules.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12010076
Abstract: Plants produce numerous structurally and functionally diverse signaling metabolites, yet only relatively small fractions of which have been discovered. Multi-omics has greatly expedited the discovery as evidenced by increasing recent works reporting new plant signaling… read more here.
Keywords: multi omics; signaling molecules; omics based; plant signaling ... See more keywords