Abstract 6901: Imipridones (ONC201, ONC206 and ONC212) modulate MGMT and ClpX expression in DIPG cell lines
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DOI: 10.1158/1538-7445.am2025-6901
Abstract: The first-in-class small-molecule imipridone ONC201/Dordaviprone targets mitochondrial protease ClpP to disrupt oxidative phosphorylation and trigger integrated stress response (ISR), TRAIL/DR5, and tumor cell death. ONC201 and analog ONC206 and ONC212 are blood-brain barrier penetrant. Temozolomide… read more here.
Keywords: onc206 onc212; cell; mgmt; expression ... See more keywords