Quantitative characterization of human oncogene promoter G‐quadruplex DNA‐ligand interactions using a combination of mass spectrometry and capillary electrophoresis
Sign Up to like & getrecommendations! Published in 2021 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202100077
Abstract: Human c‐KIT oncogene is known to regulate cell growth and proliferation, and thus, acts as a probable target in the treatment of gastrointestinal tumors (GIST). To identify small molecule ligands which can specifically bind with… read more here.
Keywords: capillary electrophoresis; combination; oncogene; mass spectrometry ... See more keywords
Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Hematology"
DOI: 10.1007/s00277-019-03713-y
Abstract: Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi)-based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of siRNA to the liver; however,… read more here.
Keywords: oncogene; cml; vivo; delivery sirna ... See more keywords
SOD1 is essential for oncogene-driven mammary tumor formation but dispensable for normal development and proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0839-x
Abstract: We previously reported that the dismutase SOD1 is overexpressed in breast cancer. However, whether SOD1 plays an active role in tumor formation in vivo has never been demonstrated. Further, as luminal cells of normal breast… read more here.
Keywords: sod1 essential; oncogene; sod1; proliferation ... See more keywords
Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002891
Abstract: Background Non-small cell lung cancer (NSCLC) patients bearing targetable oncogene alterations typically derive limited benefit from immune checkpoint blockade (ICB), which has been attributed to low tumor mutation burden (TMB) and/or PD-L1 levels. We investigated… read more here.
Keywords: benefit icb; benefit; oncogene; expression ... See more keywords
Abstract B18: Novel treatment of cutaneous T cell lymphoma: Targeting TNFR2, an oncogene and marker of potent Tregs, with anti-TNFR2 antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-b18
Abstract: Background: Tumor necrosis factor receptor 2 (TNFR2, or TNFRSF1B) is a lymphoid marker of the most potent regulatory T cell (Treg) subtype and a commonly expressed oncogene in human tumors. TNFR2 Tregs are also enriched… read more here.
Keywords: oncogene; tnfr2; tnfr2 antagonism; cell ... See more keywords
Immunotherapy in oncogene addicted non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Translational lung cancer research"
DOI: 10.21037/tlcr-20-772
Abstract: The use of immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) has led to notable changes in treatment strategies for patients with advanced non-small cell lung cancer… read more here.
Keywords: non small; oncogene; cell; lung cancer ... See more keywords
Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230426093244
Abstract: The sarcoma virus oncogene (Src) tyrosine kinase, a nonreceptor protein-tyrosine kinase, plays a crucial role in cell survival, migration, differentiation and proliferation. The study of Src has developed considerably since it was first discovered as… read more here.
Keywords: sarcoma virus; related diseases; oncogene; virus oncogene ... See more keywords
Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (Fancd2−/−) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene
Sign Up to like & getrecommendations! Published in 2019 at "In Vivo"
DOI: 10.21873/invivo.11476
Abstract: Aim: To demonstrate that Fanconi anemia complementation group D2-deficient (Fancd2−/−) hematopoietic progenitor cell lines can be transformed by transfection with a plasmid containing either the E6 or E7 oncogene of human papillomavirus (HPV) to generate… read more here.
Keywords: oncogene; cell lines; malignant transformation; hematopoietic progenitor ... See more keywords
bub1 as a potential oncogene and a prognostic biomarker for neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.988415
Abstract: Background Neuroblastoma is the most common malignant extracranial tumor for children. Molecular mechanisms underpinning the pathogenesis of this disease are yet to be fully clarified. This study aimed to identify a novel oncogene that could… read more here.
Keywords: expression; prognostic biomarker; neuroblastoma; bub1 ... See more keywords
Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells
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DOI: 10.3390/cancers12020395
Abstract: Lesions with driver mutations, including atypical nevi and seborrheic keratoses, are very common in dermatology, and are prone to senescence. The molecular events that prevent senescent lesions from becoming malignant are not well understood. We… read more here.
Keywords: oncogene; temperature; senescence; large antigen ... See more keywords
A Comprehensive Pan-Cancer Analysis Identifies CEP55 as a Potential Oncogene and Novel Therapeutic Target
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13091613
Abstract: Emerging research findings have shown that a centrosomal protein (CEP55) is a potential oncogene in numerous human malignancies. Nevertheless, no pan-cancer analysis has been conducted to investigate the various aspects and behavior of this oncogene… read more here.
Keywords: cep55 potential; potential oncogene; pan cancer; analysis ... See more keywords