Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "ESMO open"
DOI: 10.1016/j.esmoop.2022.100465
Abstract: BACKGROUND Frontline immune checkpoint inhibitors (ICI)-based regimens in non-oncogene-addicted non-small-cell lung cancer (NSCLC) have been deeply investigated. To rank the available therapeutic options, we carried out a systematic review and Bayesian meta-analysis. METHODS A comprehensive… read more here.
Keywords: meta analysis; oncogene addicted; non oncogene; checkpoint inhibitors ... See more keywords
SBRT for oligoprogressive oncogene addicted NSCLC.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2017.02.007
Abstract: Lung cancer is one of the leading causes of cancer death in men and women and treatment outcome continues to lag behind other common cancer types. A subset of lung adenocarcinoma patients exhibit a somatic… read more here.
Keywords: treatment; addicted nsclc; oligoprogressive oncogene; oncogene addicted ... See more keywords
Anti-angiogenic agents in the age of resistance to immune checkpoint inhibitors: Do they have a role in non-oncogene-addicted non-small cell lung cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.04.009
Abstract: The introduction of licensed front-line immunotherapies has heralded a new era for the treatment of non-oncogene-addicted, advanced non-small cell lung cancer (NSCLC). Yet as with all evolutions in clinical management, changes in practice can outpace… read more here.
Keywords: evidence; oncogene addicted; lung cancer; non oncogene ... See more keywords
Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2018.101076
Abstract: The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we… read more here.
Keywords: drug resistance; resistance; oncogene addicted; cancer cells ... See more keywords
Immune checkpoint inhibitor treatment in patients with oncogene-addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion
Sign Up to like & getrecommendations! Published in 2019 at "ESMO Open"
DOI: 10.1136/esmoopen-2019-000498
Abstract: The introduction of targeted treatments and more recently immune checkpoint inhibitors (ICI) to the treatment of metastatic non-small cell lung cancer (NSCLC) has dramatically changed the prognosis of selected patients. For patients with oncogene-addicted metastatic… read more here.
Keywords: patients oncogene; immune checkpoint; nsclc; treatment ... See more keywords
Oncogene-addicted non-small cell lung cancer and immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.01.82
Abstract: A majority of non-small cell lung cancer (NSCLC), especially adenocarcinomas, harbour at least one oncogenic driver mutation that can potentially be a target for therapy. The treatment of these oncogene-addicted tumors has dramatically changed the… read more here.
Keywords: oncogene addicted; non small; cancer; cell ... See more keywords
The optional approach of oncogene-addicted non-small cell lung cancer with brain metastases in the new generation targeted therapies era.
Sign Up to like & getrecommendations! Published in 2019 at "Translational lung cancer research"
DOI: 10.21037/tlcr.2019.12.24
Abstract: In recent years, the study of the molecular characteristics of non-small cell lung cancer (NSCLC) has highlighted a specific role of some genes that represent important therapeutic targets, including epidermal growth factor receptor (EGFR), anaplastic… read more here.
Keywords: lung cancer; oncogene addicted; non small; cancer ... See more keywords
Oncogene-Addicted Non-Small-Cell Lung Cancer: Treatment Opportunities and Future Perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051196
Abstract: Before the introduction of tyrosine kinase inhibitors (TKIs) for a particular subgroup of patients, despite platinum-based combination chemotherapy, the majority of patients affected by non-small-cell lung cancer (NSCLC) did not live longer than one year.… read more here.
Keywords: treatment; oncogene addicted; non small; cancer ... See more keywords
Role of Radiosurgery and Stereotactic Ablative Radiotherapy for Oligometastatic Non-Oncogene Addicted NSCLC
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061465
Abstract: Simple Summary The definition and management of oligometastatic NSCLC have been incorporated into current guidelines on lung cancer, supporting the use of a definitive treatment with curative intent, including the focal ablation of all sites… read more here.
Keywords: non oncogene; stereotactic ablative; ablative radiotherapy; progression ... See more keywords