High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation
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DOI: 10.1101/gr.276028.121
Abstract: Genomic rearrangements are known to result in proto-oncogene deregulation in many cancers, but the link to genome 3D structure remains poorly understood. Here we used the highly-predictive heteromorphic polymer (HiP-HoP) model to predict chromatin conformations… read more here.
Keywords: ccnd1; proto oncogene; genomic rearrangements; oncogene deregulation ... See more keywords