Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6670-7_8
Abstract: Oncogene-induced senescence (OIS) is a highly dynamic process, involving several different effector mechanisms, the multitude and combination of which likely determines the quality of the phenotype (Pérez-Mancera et al., Nat Rev Cancer 14:547-558, 2014). Autophagy,… read more here.
Keywords: methods mol; oncogene induced; microscopy; senescence ... See more keywords
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.04.030
Abstract: The Ras genes are the most frequently mutated oncogenes in human cancer. However, Ras biology is quite complex. While Ras promotes tumorigenesis by regulating numerous growth promoting pathways, activated Ras can paradoxically also lead to… read more here.
Keywords: oncogene induced; role nore1a; nore1a tumor; induced senescence ... See more keywords
Oncogene-induced regulation of microRNA expression: Implications for cancer initiation, progression and therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.02.029
Abstract: A plethora of tumours have characteristic oncogenic mutations which are the main causes of malignant transformation, exerting their effects through multiple signalling pathways. Downstream of such pathways, microRNAs are small non-coding RNAs that negatively regulate… read more here.
Keywords: cancer; expression; initiation progression; oncogene induced ... See more keywords
Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45955-z
Abstract: Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset and evolution of cancer. Despite its critical role in cancer, the mechanisms that generate oncogene-induced… read more here.
Keywords: oncogene induced; replication; induced replication; replication stress ... See more keywords
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89220-5
Abstract: Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX-2 are not… read more here.
Keywords: oncogene induced; neoplastic transformation; cox; induced senescence ... See more keywords
Selective degradation of ribosomes during oncogene-induced senescence: molecular insights and biological perspectives
Sign Up to like & getrecommendations! Published in 2024 at "Autophagy"
DOI: 10.1080/15548627.2024.2319022
Abstract: ABSTRACT Ribosomes are conserved macromolecular machines that are responsible for protein synthesis in all cells. While our knowledge of ribosome biogenesis and function has increased significantly in recent years, little is known about how ribosomes… read more here.
Keywords: senescence; oncogene induced; induced senescence; ribosomes oncogene ... See more keywords
Abstract 5464: Pharmacologic activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5464
Abstract: The circadian clock drives daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer, and circadian rhythm disruption predisposes to tumor development in animal models and… read more here.
Keywords: rev; oncogene induced; rev erb; cancer ... See more keywords
Transcriptomic landscape of Hras12V oncogene-induced hepatocarcinogenesis with gender disparity
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-13476-7
Abstract: The genesis of hepatocellular carcinoma (HCC) is closely related to male factors and hyper-activated Ras signals. A transcriptomic database was established via RNA-Seq of HCC (T) and the adjacent precancerous liver tissue (P) of Hras12V… read more here.
Keywords: hras12v; oncogene induced; transcriptomic landscape; landscape hras12v ... See more keywords
Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue
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DOI: 10.1186/s12885-025-13499-0
Abstract: Oncogene-Induced Senescence (OIS) is a form of senescence that occurs as a consequence of oncogenic overstimulation and possibly infection by oncogenic viruses. Whether senescence plays a role in the pathogenesis of cervical cancer (CC) is… read more here.
Keywords: senescence; hpv; cancer; oncogene induced ... See more keywords
Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology"
DOI: 10.1186/s13059-018-1494-1
Abstract: BackgroundFunctional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncogene-induced senescence, a cellular state of irreversible… read more here.
Keywords: induced senescence; enhancer; crispr; oncogene induced ... See more keywords
Variable Expression of Oncogene-Induced Senescence/SASP Surrogates in HPV-Associated Precancerous Cervical Tissue
Sign Up to like & getrecommendations! Published in 2024 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb46120818
Abstract: Oncogene-induced senescence (OIS) is a form of cellular senescence triggered by oncogenic signaling and, potentially, by infection with oncogenic viruses. The role of senescence, along with its associated secretory phenotype, in the development of cervical… read more here.
Keywords: senescence; oncogene induced; sasp; precancerous lesions ... See more keywords