CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling
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DOI: 10.1186/s13073-019-0627-9
Abstract: CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in. Here we developed CRISPR-based… read more here.
Keywords: somatic oncogene; knock; crispr; cancer modeling ... See more keywords