Astrocyte elevated gene-1 as a novel therapeutic target in malignant gliomas and its interactions with oncogenes and tumor suppressor genes
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DOI: 10.1016/j.brainres.2020.147034
Abstract: Astrocyte elevated gene-1 (AEG-1) is an oncogene and a critical signaling molecule that has a wide variety of interactions with other oncogenes and tumor suppressor genes, leading to increasing malignant properties of malignant gliomas, such… read more here.
Keywords: interactions oncogenes; gliomas; malignant gliomas; oncogenes tumor ... See more keywords
Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review
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DOI: 10.21873/anticanres.14622
Abstract: Cancer is a medical condition which has a molecular basis. Proto-oncogenes are the first regulatory factors of this biological process. They act in transmitting signals, resulting as growth factors. Modifications of these genes, called oncogenes,… read more here.
Keywords: tumor suppressor; oncogenes tumor; suppressor genes; development ... See more keywords
Comparative Analysis of microRNA Binding Site Distribution and microRNA-Mediated Gene Expression Repression of Oncogenes and Tumor Suppressor Genes
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DOI: 10.3390/genes13030481
Abstract: MicroRNAs (miRNAs) are a family of short, noncoding RNAs that can regulate gene expression levels of over half of the human genome. Previous studies on the role of miRNAs in cancer showed overall widespread downregulation… read more here.
Keywords: gene; gene expression; microrna; oncogenes tumor ... See more keywords
KRAB-ZFP Transcriptional Regulators Acting as Oncogenes and Tumor Suppressors: An Overview
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DOI: 10.3390/ijms22042212
Abstract: Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB-ZFPs have a dual structure. They may bind to specific DNA sequences via zinc… read more here.
Keywords: oncogenes tumor; cancer; zfps; tumor suppressors ... See more keywords
Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence
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DOI: 10.3390/metabo13040560
Abstract: Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based… read more here.
Keywords: suppressor genes; tumor suppressor; ovarian cancer; cancer ... See more keywords