Breaking the oncogenic alliance: advances in disrupting the MTDH–SND1 complex for cancer therapy
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra04310g
Abstract: Metadherin (MTDH/AEG-1/LYRIC) partners with Staphylococcal Nuclease Domain-Containing Protein 1 (SND1) to form an oncogenic hub that drives proliferation, survival and metastasis in many tumors. Interrupting this interaction dampens pivotal pathways—including NF-κB, PI3K/Akt and Wnt/β-catenin—and simultaneously… read more here.
Keywords: breaking oncogenic; oncogenic alliance; mtdh; alliance advances ... See more keywords