CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.005
Abstract: An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including… read more here.
Keywords: tumor suppressor; chd4; oncogenic functions; chd4 oncogenic ... See more keywords
Abstract 328: Acetylation regulates the oncogenic functions of PRMT5
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-328
Abstract: Protein arginine methyltransferase 5 (PRMT5) is an enzyme responsible for symmetric arginine methylation, which governs multiple crucial cellular events. PRMT5 expression and activity are dysregulated in many malignancies. PRMT5 dynamically shuttles between the cytosol and… read more here.
Keywords: regulates oncogenic; acetylation; functions prmt5; acetylation regulates ... See more keywords
The Oncogenic Functions of MASTL Kinase
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00162
Abstract: MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase.… read more here.
Keywords: pp2a b55; oncogenic functions; kinase; mastl kinase ... See more keywords
Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer
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DOI: 10.3390/cancers13143395
Abstract: Simple Summary Over the last few years, circular RNAs (circRNAs) are highly anticipated as new diagnostic and prognostic biomarkers. Our review aimed to present new data about circRNAs as targets in oncogenic axes to inhibit… read more here.
Keywords: circular rnas; oncogenic functions; colorectal cancer; review ... See more keywords
Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20246197
Abstract: The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent, novel oncogenic functions, a phenomenon termed mutant p53… read more here.
Keywords: oncogenic functions; mutant p53; p53; gain function ... See more keywords