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   Articles with "oncogenic fusion" as a keyword



The oncogenic fusion landscape in pediatric CNS neoplasms

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recommendations! Published in 2022 at "Acta Neuropathologica"

DOI: 10.1007/s00401-022-02405-8

Abstract: Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-related deaths in children. Recent developments in molecular analyses have greatly contributed to a more accurate diagnosis and risk stratification of CNS… read more here.

Keywords: fusion; cns; pediatric cns; cns neoplasms ... See more keywords

HGG-34. DETECTION OF ONCOGENIC FUSION EVENTS IN SUPRATENTORIAL GLIOBLASTOMAS OF YOUNG CHILDREN

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.315

Abstract: Abstract INTRODUCTION Glioblastoma in infancy and early childhood is characterized by a more favorable outcome compared to older children, a stable genome, and the occurrence of tyrosine kinase gene fusions that may represent therapeutic targets.… read more here.

Keywords: gene fusions; hgg detection; four years; detection oncogenic ... See more keywords

Epigenetic Therapies.

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recommendations! Published in 2024 at "Cold Spring Harbor perspectives in medicine"

DOI: 10.1101/cshperspect.a041637

Abstract: Epigenetic therapies are emerging for pediatric cancers. Due to the relatively low mutational burden in pediatric tumors, epigenetic dysregulation and differentiation blockade is a hallmark of oncogenesis in some childhood cancers. By targeting epigenetic regulators… read more here.

Keywords: pediatric tumors; oncogenic fusion; epigenetic dysregulation; epigenetic therapies ... See more keywords

Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity.

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recommendations! Published in 2023 at "Science advances"

DOI: 10.1126/sciadv.abo3789

Abstract: Cell fate transitions observed in embryonic development involve changes in three-dimensional genomic organization that provide proper lineage specification. Whether similar events occur within tumor cells and contribute to cancer evolution remains largely unexplored. We modeled… read more here.

Keywords: cell; oncogenic fusion; fusion protein; highly connected ... See more keywords