The oncogenic fusion landscape in pediatric CNS neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neuropathologica"
DOI: 10.1007/s00401-022-02405-8
Abstract: Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-related deaths in children. Recent developments in molecular analyses have greatly contributed to a more accurate diagnosis and risk stratification of CNS… read more here.
Keywords: fusion; cns; pediatric cns; cns neoplasms ... See more keywords
HGG-34. DETECTION OF ONCOGENIC FUSION EVENTS IN SUPRATENTORIAL GLIOBLASTOMAS OF YOUNG CHILDREN
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.315
Abstract: Abstract INTRODUCTION Glioblastoma in infancy and early childhood is characterized by a more favorable outcome compared to older children, a stable genome, and the occurrence of tyrosine kinase gene fusions that may represent therapeutic targets.… read more here.
Keywords: gene fusions; hgg detection; four years; detection oncogenic ... See more keywords
Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.abo3789
Abstract: Cell fate transitions observed in embryonic development involve changes in three-dimensional genomic organization that provide proper lineage specification. Whether similar events occur within tumor cells and contribute to cancer evolution remains largely unexplored. We modeled… read more here.
Keywords: cell; oncogenic fusion; fusion protein; highly connected ... See more keywords