Oncogenic gain of function due to p53 amyloids by aberrant alteration of cell cycle and proliferation.
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DOI: 10.1242/jcs.259500
Abstract: Transcription factor p53 has been shown to aggregate into cytoplasmic/nuclear inclusions, compromising its native tumor suppressive functions. Recently, p53 is shown to form amyloids, which play a role in conferring cancerous properties to cells leading… read more here.
Keywords: oncogenic gain; cell; p53 amyloid; cell cycle ... See more keywords