RAGE maintains high levels of NFκB and oncogenic Kras activity in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.147
Abstract: Oncogenic KRas activity is central to several cancer types including pancreatic ductal adenocarcinoma (PDAC) but has been determined to be "undruggable". Recent studies have indicated that oncogenic KRas is not constitutively active but relies on… read more here.
Keywords: pdac; oncogenic kras; rage; cancer ... See more keywords
Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b01113
Abstract: RAS mutations are found in 30% of all human cancers, with KRAS the most frequently mutated among the three RAS isoforms (KRAS, NRAS, and HRAS). However, directly targeting oncogenic KRAS with small molecules in the… read more here.
Keywords: nucleotide binding; oncogenic kras; binding site; small molecules ... See more keywords
Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b02988
Abstract: The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated… read more here.
Keywords: total chemical; variants oncogenic; oncogenic kras; chemical synthesis ... See more keywords
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07472-8
Abstract: Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We previously described a role for KRAS in PDAC tumor maintenance through rewiring of cellular metabolism to support proliferation. Understanding the details of this… read more here.
Keywords: pdac; oncogenic kras; kras supports; kras resistant ... See more keywords
Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113180119
Abstract: Significance We report a molecular brush-based oligonucleotide therapeutics platform which uniquely provides conjugated antisense oligonucleotides with binding selectivity, improved pharmacological properties, and an unusual biodistribution profile. These improvements lead to superior in vivo performance compared… read more here.
Keywords: conjugated antisense; targeting oncogenic; antisense oligonucleotides; oncogenic kras ... See more keywords
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2018.1450708
Abstract: ABSTRACT Defects in basal autophagy limit the nutrient supply from recycling of intracellular constituents. Despite our understanding of the prosurvival role of macroautophagy/autophagy, how nutrient deprivation, caused by compromised autophagy, affects oncogenic KRAS-driven tumor progression… read more here.
Keywords: tumorigenesis; oncogenic kras; driven tumor; autophagic reliance ... See more keywords
Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "BMC Cancer"
DOI: 10.1101/2022.05.20.492866
Abstract: Background Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes. However, the majority of… read more here.
Keywords: lung; alternative splicing; oncogenic kras; cancer ... See more keywords
Oncogenic KRAS sensitizes lung adenocarcinoma to GSK-J4-induced metabolic and oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3511
Abstract: Genetic and epigenetic changes (e.g., histone methylation) contribute to cancer development and progression, but our understanding of whether and how specific mutations affect a cancer's sensitivity to histone demethylase (KDM) inhibitors is limited. Here, we… read more here.
Keywords: gsk; metabolic oxidative; oncogenic kras; cancer ... See more keywords
Abstract 2575: Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+signals that are inhibited by oncogenic KRas
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-2575
Abstract: Changes in the mechanical microenvironment and mechanical signals are observed during tumor progression, malignant transformation, and metastasis. In this context, understanding the molecular details of mechanotransduction signaling may provide unique therapeutic targets. Here we report… read more here.
Keywords: nox2 generated; oncogenic kras; mechanoactivation nox2; cancer ... See more keywords
Abstract 4140: Oncogenic KRAS inhibition with ADT-007 primes T cell responses in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4140
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) has low (90% of human PDAC tumors, provides an opportunity to inhibit a critical pathway and significantly impact standard of care in patients diagnosed with PDAC. Furthermore, evidence indicates that… read more here.
Keywords: ductal adenocarcinoma; adt 007; oncogenic kras; pancreatic ductal ... See more keywords
Abstract A10: Using single-cell RNA sequencing to assess the impact of pancreatic oncogenic Kras on macrophage gene expression in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.panca19-a10
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with only a 9% five-year survival rate in the United States. A hallmark of PDAC is the dramatic infiltration of fibroblasts and immune cells to the cancer… read more here.
Keywords: oncogenic kras; cancer; gene; tumor ... See more keywords