DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2052640
Abstract: ABSTRACT Chronic inflammation and oncogenic pathway activation are key-contributing factors in colorectal cancer pathogenesis. However, colorectal intrinsic mechanisms linking these two factors in cancer development are poorly defined. Here, we show that intestinal epithelial cell… read more here.
Keywords: oncogenic pathway; colorectal cancer; activation; colorectal carcinogenesis ... See more keywords
Abstract A010: Using oncogenic pathway agonism to sensitize RAS-mutant cancers to immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a010
Abstract: Overall, some 30% of human cancers are driven by mutant RAS proteins, which have proven relatively difficult to target. While immunotherapy is effective for NRAS-mutant melanoma, no options exist for resistant disease, and mutant KRAS-driven… read more here.
Keywords: oncogenic pathway; ras mutant; sensitize ras; pathway agonism ... See more keywords