Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21761
Abstract: Development and progression of metastasis comprises synchronized erroneous expressions of several composite pathways, which are difficult to manage simultaneously with the representative anticancer molecules. The emergence of the drug resistance and the complex interplay between… read more here.
Keywords: barbiturate derivatives; derivatives managing; managing multifaceted; multifaceted oncogenic ... See more keywords
A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.066
Abstract: Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely… read more here.
Keywords: mcl; cell lymphomas; notch; small cell ... See more keywords
Differential effects of thymoquinone on lysophosphatidic acid-induced oncogenic pathways in ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2020.04.001
Abstract: Thymoquinone, a therapeutic phytochemical derived from Nigella sativa, has been shown to have a potent anticancer activity. However, it has been identified that the tumor microenvironment (TME) can attenuate the anticancer effects of thymoquinone (TQ)… read more here.
Keywords: pathways ovarian; ovarian cancer; lpa; cancer cells ... See more keywords
Impact of oncogenic pathways on evasion of antitumour immune responses
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2017.117
Abstract: Immunotherapeutic interventions are showing effectiveness across a wide range of cancer types, but only a subset of patients shows clinical response to therapy. Responsiveness to checkpoint blockade immunotherapy is favoured by the presence of a… read more here.
Keywords: pathways evasion; immune responses; evasion antitumour; impact oncogenic ... See more keywords
Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba4905
Abstract: Germline variants when organized as genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes. There is an ongoing debate on the importance of genetic factors in cancer development, where gene-centered cancer predisposition… read more here.
Keywords: genomic patterns; clinical outcomes; cancer risk; cancer ... See more keywords
Ginkgo biloba induces different gene expression signatures and oncogenic pathways in malignant and non-malignant cells of the liver
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209067
Abstract: Ginkgo biloba (EGb761) is a widely used botanical drug. Several reports indicate that EGb761 confers preventive as well as anti-tumorigenic properties in a variety of tumors, including hepatocellular carcinoma (HCC). We here evaluate functional effects… read more here.
Keywords: ginkgo biloba; malignant cells; hepatoma cells; tumorigenic properties ... See more keywords
Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302137
Abstract: Colorectal cancer is a complex disease driven by well-established mutations such as APC and other yet to be identified pathways. The GTPase Rab11 regulates endosomal protein trafficking, and previously we showed that loss of Rab11… read more here.
Keywords: rab11; metabolism; loss rab11; cancer ... See more keywords
Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.883639
Abstract: Despite the broad application of different immunotherapeutic strategies for the treatment of solid as well as hematopoietic cancers, the efficacy of these therapies is still limited, with only a minority of patients having a long-term… read more here.
Keywords: functions microenvironment; tumor; modulation lymphocyte; lymphocyte functions ... See more keywords
The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14030848
Abstract: Simple Summary Oncoviruses are viruses with oncogenic potential, responsible for almost 20% of human cancers worldwide. They are from various families, some of which belong to the microbial communities that inhabit several sites in the… read more here.
Keywords: system; chemokines receptors; chemokine system; host responses ... See more keywords
NRF2 in Cancer: Cross-Talk with Oncogenic Pathways and Involvement in Gammaherpesvirus-Driven Carcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010595
Abstract: Expanding knowledge of the molecular mechanisms at the basis of tumor development, especially the cross-talk between oncogenic pathways, will possibly lead to better tailoring of anticancer therapies. Nuclear factor erythroid 2-related factor 2 (NRF2) plays… read more here.
Keywords: cross talk; gammaherpesvirus driven; oncogenic pathways; cancer ... See more keywords
Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.30199
Abstract: Background: Transcription factor ISL1 plays a critical role in sympathetic neurogenesis. Expression of ISL1 has been associated with neuroblastoma, a pediatric tumor derived from sympatho-adrenal progenitors, however the role of ISL1 in neuroblastoma remains unexplored.… read more here.
Keywords: isl1 gata3; isl1; mycn; neuroblastoma ... See more keywords