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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.066
Abstract: PI3K/Akt/mTOR pathway is crucial for carcinogenesis and its inhibitors have made a great progress in cancer treatment. However, there is still a great developing space for PI3K inhibitors as the acquired drug resistance hindered their…
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Keywords:
oncogenic pi3k;
degradation;
pi3k;
conjugations degradation ... See more keywords
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Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-0446
Abstract: Transcriptomic analysis reveals a key role for the PI3K pathway in regulating RNA splicing, uncovering new mechanisms by which PI3K regulates proliferation and metabolism in breast cancer.
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Keywords:
pi3k;
reveals key;
induced transcriptomic;
pi3k induced ... See more keywords