RNA-seq Based Transcription Characterization of Fusion Breakpoints as a Potential Estimator for Its Oncogenic Potential
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/9829175
Abstract: Based on high-throughput sequencing technology, the detection of gene fusions is no longer a big challenge but estimating the oncogenic potential of fusion genes remains challenging. Recent studies successfully applied machine learning methods and gene… read more here.
Keywords: oncogenic potential; fusion clone; fusion mutation; fusion ... See more keywords
The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0359
Abstract: Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a… read more here.
Keywords: stat3; stat3 acetylation; sin3a; cell ... See more keywords
Genome composition-based deep learning predicts oncogenic potential of HPVs
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2024.1430424
Abstract: Human papillomaviruses (HPVs) account for more than 30% of cancer cases, with definite identification of the oncogenic role of viral E6 and E7 genes. However, the identification of high-risk HPV genotypes has largely relied on… read more here.
Keywords: deep learning; based deep; hpvs; oncogenic potential ... See more keywords
Oncogenic Potential of the Dual-Function Protein MEX3A
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10050415
Abstract: Simple Summary RNA-binding proteins (RBPs) are involved in the post-transcriptional control of gene expression, modulating the splicing, turnover, subcellular sorting and translation of (m)RNAs. Dysregulation of RBPs, for instance, by deregulated expression in cancer, disturbs… read more here.
Keywords: protein; oncogenic potential; rna binding; expression ... See more keywords
Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs) Harboring Oncogenic Potential and Is Markedly Upregulated in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11081174
Abstract: Simple Summary Clinical and molecular advances have improved knowledge and treatment prospects for cancer, yet hepatocellular carcinoma (HCC), the most common form of liver cancer, still ranks significantly higher in terms of the global cancer… read more here.
Keywords: oncogenic potential; hepatocellular carcinoma; hcc; protein signaling ... See more keywords