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Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/9829175
Abstract: Based on high-throughput sequencing technology, the detection of gene fusions is no longer a big challenge but estimating the oncogenic potential of fusion genes remains challenging. Recent studies successfully applied machine learning methods and gene…
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Keywords:
oncogenic potential;
fusion clone;
fusion mutation;
fusion ... See more keywords
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Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0359
Abstract: Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a…
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Keywords:
stat3;
stat3 acetylation;
sin3a;
cell ... See more keywords
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Published in 2021 at "Biology"
DOI: 10.3390/biology10050415
Abstract: Simple Summary RNA-binding proteins (RBPs) are involved in the post-transcriptional control of gene expression, modulating the splicing, turnover, subcellular sorting and translation of (m)RNAs. Dysregulation of RBPs, for instance, by deregulated expression in cancer, disturbs…
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Keywords:
protein;
oncogenic potential;
rna binding;
expression ... See more keywords
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Published in 2022 at "Biology"
DOI: 10.3390/biology11081174
Abstract: Simple Summary Clinical and molecular advances have improved knowledge and treatment prospects for cancer, yet hepatocellular carcinoma (HCC), the most common form of liver cancer, still ranks significantly higher in terms of the global cancer…
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Keywords:
oncogenic potential;
hepatocellular carcinoma;
hcc;
protein signaling ... See more keywords