Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1668-3
Abstract: Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1–3. A subset of gastrointestinal stromal tumours (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase (SDH) deficiency and global… read more here.
Keywords: deficient gists; topology; oncogenic programs; sdh deficient ... See more keywords
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aao4750
Abstract: The cellular composition of H3K27M gliomas Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin et al. used a single-cell sequencing approach… read more here.
Keywords: single cell; genetics; oncogenic programs; h3k27m gliomas ... See more keywords