Oncogenic RAS drives the CRAF‐dependent extracellular vesicle uptake mechanism coupled with metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12091
Abstract: Abstract Oncogenic RAS impacts communication between cancer cells and their microenvironment, but it is unclear how this process influences cellular interactions with extracellular vesicles (EVs). This is important as intercellular EV trafficking plays a key… read more here.
Keywords: ras drives; mechanism; metastasis; oncogenic ras ... See more keywords
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.01.013
Abstract: The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene… read more here.
Keywords: gene essentiality; gene networks; oncogenic ras; gene ... See more keywords
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.016
Abstract: Summary The immunosuppressive protein PD‐L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor microenvironment and cancer cell‐intrinsic signaling in the regulation of PD‐L1… read more here.
Keywords: ttp; expression; ras signaling; oncogenic ras ... See more keywords
Eliminating oncogenic RAS: back to the future at the drawing board
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20221343
Abstract: RAS drug development has made enormous strides in the past ten years, with the first direct KRAS inhibitor being approved in 2021. However, despite the clinical success of covalent KRAS-G12C inhibitors, we are immediately confronted… read more here.
Keywords: small molecule; back future; oncogenic ras; eliminating oncogenic ... See more keywords
Targeting RAS in pediatric cancer: is it becoming a reality?
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000000856
Abstract: PURPOSE OF REVIEW The current review aims to highlight the frequency of RAS mutations in pediatric leukemias and solid tumors and to propose strategies for targeting oncogenic RAS in pediatric cancers. RECENT FINDINGS The three… read more here.
Keywords: targeting ras; ras mutations; cancer; pediatric cancer ... See more keywords
RAS, wanted dead or alive: Advances in targeting RAS mutant cancers
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aay6013
Abstract: New signaling insights level the playing field against the notoriously “undruggable” protein RAS. Oncogenic RAS proteins, which are mutated in approximately 24% of all human cancers, have earned a well-deserved reputation as being “undruggable.” However,… read more here.
Keywords: ras proteins; ras wanted; ras mutant; wanted dead ... See more keywords
Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2727
Abstract: How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas, HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How they selectively activate effectors and why is KRas4B the most prevalent… read more here.
Keywords: oncogenic ras; specificity membrane; membrane; ras isoforms ... See more keywords
Abstract 3993: Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, NF1 loss and RAS-GTP-dependent oncogenic BRAF
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3993
Abstract: Oncogenic alterations in the RAS-RAF-MEK-ERK pathway, including mutant forms of KRAS, BRAF, and loss of the tumor suppressor and RAS GTPase-activating protein (GAP) NF1, drive the growth of a wide spectrum of cancers. While BRAF… read more here.
Keywords: oncogenic braf; oncogenic ras; ras gtp; nf1 loss ... See more keywords
Abstract B48: Oncogenic Ras reprograms metabolism by suppressing TXNIP translation
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.transcontrol16-b48
Abstract: Salt Lake City, UT. Background: Oncogenic Ras promotes aerobic glycolysis and glutaminolysis to supply central carbon metabolism. Ras-transformed cells also upregulate autophagy and internalization of extracellular proteins and lipids to fuel their enhanced metabolic needs.… read more here.
Keywords: metabolism; txnip translation; oncogenic ras; translation ... See more keywords
Abstract A037: Oncogenic RAS signals from lysosomes to activate mTORC1 in multiple myeloma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a037
Abstract: Oncogenic mutations of both NRAS and KRAS are common in multiple myeloma (MM), an incurable malignancy of plasma cells. However, the mechanisms of pathogenic RAS signaling in MM have remained enigmatic, and there is little… read more here.
Keywords: oncogenic ras; ras signals; ras signaling; multiple myeloma ... See more keywords
Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.673096
Abstract: Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States… read more here.
Keywords: ras activity; ras; oncogenic ras; ras driven ... See more keywords