Extracellular vesicles and oncogenic signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12855
Abstract: In recent years, extracellular vesicles (EVs) emerged as potential diagnostic and prognostic markers for cancer therapy. While the field of EV research is rapidly developing and their application as vehicles for therapeutic cargo is being… read more here.
Keywords: extracellular vesicles; oncogenic signaling; signaling cascades; vesicles oncogenic ... See more keywords
The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of cancer"
DOI: 10.1002/ijc.34486
Abstract: Oncogene-induced hyper-proliferation in cancer cells is accompanied by the onset of different stresses, including DNA-replication stress, metabolic stress and oxidative stress. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal and contradictory role in… read more here.
Keywords: oxidative stress; oncogenic signaling; stress ferroptosis; ferroptosis ... See more keywords
Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT/mTOR pathways
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23731
Abstract: Cadmium (Cd) is an environmental pollutant that increases hepatotoxicity and the risk of liver diseases. In the current study, we investigated the effect of a physiologically relevant, low concentration of Cd on the regulation of… read more here.
Keywords: liver; akt mtor; oncogenic signaling; notch akt ... See more keywords
Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Cell"
DOI: 10.1016/j.devcel.2020.01.004
Abstract: Summary To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We… read more here.
Keywords: mechanics; confinement; oncogenic signaling; signaling alters ... See more keywords
Uveal melanoma–associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abj4243
Abstract: Description Mutant forms of a phospholipase C isoform mediate oncogenic signaling in uveal melanoma. A driver oncogene for uveal melanoma Uveal melanoma (UM) is an aggressive form of cancer that arises in the eye and… read more here.
Keywords: uveal melanoma; plc; proliferation; oncogenic signaling ... See more keywords
Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abc2823
Abstract: Blocking MLK4-mediated IL-17RB phosphorylation diminishes downstream signaling and suppresses pancreatic cancer progression and metastasis. A “loop”-hole for pancreatic cancer treatment Tumor cells exploit signaling pathways involved in cell survival, proliferation, and migration to promote tumor… read more here.
Keywords: pancreatic cancer; metastasis; oncogenic signaling; cancer ... See more keywords
Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2320
Abstract: Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate oncogenic signaling in TEC. In this study, we evaluated the cross-talk between CAF and TEC isolated from tumors… read more here.
Keywords: associated fibroblasts; pancreatic cancer; oncogenic signaling; cancer ... See more keywords
Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07285-3
Abstract: Background SOCS1 and SOCS3 genes are considered tumor suppressors in hepatocellular carcinoma (HCC) due to frequent epigenetic repression. Consistent with this notion, mice lacking SOCS1 or SOCS3 show increased susceptibility to diethylnitrosamine (DEN)-induced HCC. As… read more here.
Keywords: socs1; hcc; pathway genes; oncogenic signaling ... See more keywords
ST6Gal1: Oncogenic signaling pathways and targets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.962908
Abstract: The Golgi-sialyltransferase ST6Gal1 (βgalactosidase α2,6 sialyltransferase 1), adds the negatively charged sugar, sialic acid, to the terminal galactose of N-glycosylated proteins. Upregulation of ST6Gal1 is observed in many malignancies, and a large body of research… read more here.
Keywords: oncogenic signaling; signaling pathways; st6gal1 oncogenic; pathways targets ... See more keywords
Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020212
Abstract: Withaferin-A (Wi-A), a secondary metabolite extracted from Ashwagandha (Withania somnifera), has been shown to possess anticancer activity. However, the molecular mechanism of its action and the signaling pathways have not yet been fully explored. We… read more here.
Keywords: abl oncogenic; oncogenic signaling; bcr abl; computational identification ... See more keywords
Prognostic Genetic Biomarkers Based on Oncogenic Signaling Pathways for Outcome Prediction in Patients with Oral Cavity Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13112709
Abstract: Simple Summary A comprehensive analysis based on mutational signatures and oncogenic signaling pathways to identify a specific subgroup of patients that had a significantly negative impact on both disease-free and overall survival in oral cavity… read more here.
Keywords: signaling pathways; cell carcinoma; squamous cell; cavity squamous ... See more keywords