Oncogenic and tumor suppressor genes expression in myeloproliferative neoplasms: The hidden side of a complex pathology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24289
Abstract: The present study aimed to explore the changes in the expressions of six tumor‐related genes in myeloproliferative neoplasms (MPNs). The study population included 130 patients with MPNs (52 with chronic myeloid leukemia (CML), 49 with… read more here.
Keywords: oncogenic tumor; suppressor genes; tumor suppressor; pathology ... See more keywords
Oncogenic and tumor-suppressive functions of the RNA demethylase FTO.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3710
Abstract: The epitranscriptome represents the more than 140 types of chemically varying and reversable RNA modifications affecting RNA fate. Among these, the most relevant for this review are the mRNA-modifications N6-methyladenosine (m6A) and N6,2'-O-dimethyladenosine (m6Am). Epitranscriptomic… read more here.
Keywords: oncogenic tumor; demethylase; cancer; fto ... See more keywords
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s157724
Abstract: Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the… read more here.
Keywords: sirt4; activity cancer; suppressive activity; cancer ... See more keywords
IκB-α: At the crossroad between oncogenic and tumor-suppressive signals
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DOI: 10.3892/ol.2016.5465
Abstract: Nuclear factor κB (NF-κB) is an essential component of tumorigenesis and resistance to cancer treatments. NFKB inhibitor α (IκB-α) acts as a negative regulator of the classical NF-κB pathway through its ability to maintain the… read more here.
Keywords: crossroad oncogenic; suppressive signals; cancer; tumor suppressive ... See more keywords