The expanding landscape of ‘oncohistone’ mutations in human cancers
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1038-1
Abstract: Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in… read more here.
Keywords: histone mutations; oncohistone mutations; mutations occur; expanding landscape ... See more keywords
Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-ribosylation.
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DOI: 10.1158/0008-5472.can-22-0742
Abstract: Recent studies have identified cancer-associated mutations in histone genes that lead to the expression of mutant versions of core histones called oncohistones. Many oncohistone mutations occur at Asp and Glu residues, two amino acids known… read more here.
Keywords: growth; occur functional; oncohistone mutations; adprylation ... See more keywords