Characterization of Oncology Clinical Trials Using Germline Genetic Data
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.42370
Abstract: This cross-sectional study evaluates the features of oncology clinical trials that use germline genetic data. read more here.
Keywords: oncology; genetic data; oncology clinical; germline genetic ... See more keywords
Increasing patient participation in oncology clinical trials
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5150
Abstract: Timely recruitment of eligible participants is essential for the success of clinical trials, with insufficient accrual being the leading cause for premature termination of both oncology and nonâoncology trials. read more here.
Keywords: oncology; oncology clinical; clinical trials; participation oncology ... See more keywords
Early Termination of Oncology Clinical Trials in the United States
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5385
Abstract: The aim of this study was to evaluate the rate of early trial discontinuation of oncology trials and reasons for early termination, to assess potential trends in rates of oncology trial termination, and to perform… read more here.
Keywords: oncology; termination oncology; oncology clinical; clinical trials ... See more keywords
Recommendations for Dose Selection for Adolescent Patients in Relevant Adult Oncology Clinical Trials.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2467
Abstract: Our research supported the dose selection recommendations for adolescents in the FDA Guidance on Inclusion of Adolescent Patients in Adult Oncology Clinical Trials. The FDA Guidance states that for drugs administered as a flat dose… read more here.
Keywords: adult oncology; oncology clinical; clinical trials; body weight ... See more keywords
Modernizing adverse events analysis in oncology clinical trials using alternative approaches: rationale and design of the MOTIVATE trial
Sign Up to like & getrecommendations! Published in 2020 at "Investigational New Drugs"
DOI: 10.1007/s10637-020-00938-x
Abstract: In oncology clinical research, the analysis and reporting of adverse events is of major interest. A consistent depiction of the safety profile of a new treatment is as crucial in establishing how to use it… read more here.
Keywords: events analysis; oncology clinical; clinical trials; adverse events ... See more keywords
The clinical and prognostic significance of CMTM6/PD-L1 in oncology
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-022-02811-0
Abstract: The recent discovery of CMTM6 and to a lesser extent CMTM4, two members of the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family, as master positive regulators of PD-L1 expression, the primary ligand of programmed cell… read more here.
Keywords: oncology clinical; prognostic significance; clinical prognostic; significance cmtm6 ... See more keywords
Machine Learning in Oncology: A Clinical Appraisal.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.03.032
Abstract: Machine learning (ML) is a branch of artificial intelligence centered on algorithms which do not need explicit prior programming to function but automatically learn from available data, creating decision models to complete tasks. ML-based tools… read more here.
Keywords: medicine; machine learning; oncology clinical; learning oncology ... See more keywords
Z max test for delayed effect in immuno-oncology clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1632873
Abstract: ABSTRACT Delayed separation in survival curves has been observed in immuno-oncology clinical trials. Under this situation, the classic log-rank test may confront high power loss. In this paper, we consider a Zmax test, which is… read more here.
Keywords: immuno oncology; oncology clinical; clinical trials; zmax test ... See more keywords
Oncology clinical practice guidelines usage among physicians in Nepal.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of evaluation in clinical practice"
DOI: 10.1111/jep.13594
Abstract: OBJECTIVE Oncology clinical practice guidelines (OCPGs) are systematically developed evidence-based recommendations aimed to guide practitioners in decision making during the diagnosis, management, and treatment of cancer patients under specific circumstances, thereby optimizing clinical outcomes. However,… read more here.
Keywords: among physicians; clinical practice; oncology clinical; practice ... See more keywords
The Use of Patient-Reported Outcome Measures in Phase I Oncology Clinical Trials
Sign Up to like & getrecommendations! Published in 2021 at "Oncology"
DOI: 10.1159/000514874
Abstract: Objective: To investigate patient-reported outcome (PRO) usage in phase I oncology clinical trials, including types of PRO measures and changes over time. Methods: We analyzed ClinicalTrials.gov records of phase I oncology clinical trials completed by… read more here.
Keywords: reported outcome; phase oncology; oncology clinical; clinical trials ... See more keywords
OCTANE: Oncology Clinical Trial Annotation Engine.
Sign Up to like & getrecommendations! Published in 2019 at "JCO clinical cancer informatics"
DOI: 10.1200/cci.18.00145
Abstract: PURPOSE Many targeted therapies are currently available only via clinical trials. Therefore, routine precision oncology using biomarker-based assignment to drug depends on matching patients to clinical trials. A comprehensive and up-to-date trial database is necessary… read more here.
Keywords: clinical trial; oncology clinical; annotation; oncology ... See more keywords