A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12628
Abstract: Oncolytic viruses armed with therapeutic transgenes of interest show great potential in cancer immunotherapy. Here, a novel oncolytic adenovirus carrying a signal regulatory protein‐α (SIRPα)‐IgG1 Fc fusion gene (termed SG635‐SF) was constructed, which could block… read more here.
Keywords: protein; antitumor effect; fusion; oncolytic adenovirus ... See more keywords
Magnetic-Powered Janus Cell Robots Loaded with Oncolytic Adenovirus for Active and Targeted Virotherapy of Bladder Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202201042
Abstract: A unique robotic medical platform is designed by utilizing cell robots as the active "trojan horse" of oncolytic adenovirus (OA), capable of tumor-selective binding and killing. The OA-loaded cell robots are fabricated by entirely modifying… read more here.
Keywords: cell; bladder cancer; cell robots; oncolytic adenovirus ... See more keywords
Oncolytic adenovirus H101 ameliorate the efficacy of anti‐PD‐1 monotherapy in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4845
Abstract: Immune checkpoint blockade therapy with anti‐programmed cell death (PD)‐1 antibodies provides therapeutic effect for many patients of various cancers but remains inadequate in colorectal cancer (CRC) patients. The present study aims to assess the efficacy… read more here.
Keywords: oncolytic adenovirus; efficacy; colorectal cancer; adenovirus h101 ... See more keywords
Potent antitumor effect of tumor microenvironment‐targeted oncolytic adenovirus against desmoplastic pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31060
Abstract: Pancreatic cancer is a leading cause of cancer‐related death. Desmoplastic pancreatic tumors exhibit excessive extracellular matrix (ECM) and are thus highly resistant to anticancer therapeutics, since the ECM restricts drug penetration and dispersion. Here, we… read more here.
Keywords: potent antitumor; desmoplastic pancreatic; pancreatic cancer; oncolytic adenovirus ... See more keywords
A novel oncolytic adenovirus targeting Wnt signaling effectively inhibits cancer-stem like cell growth via metastasis, apoptosis and autophagy in HCC models.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.041
Abstract: Cancer stem cells (CSCs), which are highly differentiated and self-renewing, play an important role in the occurrence, therapeutic resistant and metastasis of hepatacellular carcinoma (HCC). Oncolytic adenoviruses have targeted killing effect on tumor cells, and… read more here.
Keywords: wnt e1a; adenovirus; e1a 24bp; cancer ... See more keywords
A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.09.009
Abstract: Currently, intratumoral injection of an oncolytic adenovirus (Ad) is the conventional administration route in clinical trials. Nonetheless, the locally administered Ad disseminates to the surrounding nontarget tissues and has short biological activity due to immunogenicity… read more here.
Keywords: oad trail; trail; immune response; oncolytic adenovirus ... See more keywords
Advances in oncolytic adenovirus therapy for pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.07.006
Abstract: Survival rates for pancreatic cancer patients have remained unchanged for the last four decades. The most aggressive, and most common, type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), which has the lowest 5-year survival… read more here.
Keywords: adenovirus therapy; pancreatic cancer; clinical trials; oncolytic adenovirus ... See more keywords
Role of innate immune responses in the effectiveness of oncolytic adenovirus as an anticancer agent
Sign Up to like & getrecommendations! Published in 2017 at "The Lancet"
DOI: 10.1016/s0140-6736(17)30457-9
Abstract: Abstract Background Ovarian cancer is the deadliest gynaecological cancer, with fewer than half of patients surviving for more than 5 years. Oncolytic viruses have been investigated as a new class of anticancer agent for this… read more here.
Keywords: anticancer agent; immune responses; infection; 922 947 ... See more keywords
Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1532763
Abstract: ABSTRACT Malignant melanoma is an aggressive type of skin cancer whose incidence is increasing globally. Although surgery is effective in early stage melanoma, patients with advanced melanoma only have a 20% 5-year survival rate. Hence,… read more here.
Keywords: a2058 melanoma; combination; melanoma; oncos 102 ... See more keywords
Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2096572
Abstract: ABSTRACT Cytokines have proven to be effective for cancer therapy, however whilst low-dose monotherapy with cytokines provides limited therapeutic benefit, high-dose treatment can lead to a number of adverse events. Interleukin 7 has shown promising… read more here.
Keywords: interleukin; oncolytic adenovirus; tumor infiltrating; tumor ... See more keywords
An Oncolytic Adenovirus Expressing SNORD44 and GAS5 Exhibits Antitumor Effect in Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Human Gene Therapy"
DOI: 10.1089/hum.2017.041
Abstract: SNORD44 is a C/D box small nucleolar RNA, and exhibits low expression in breast cancer and head and neck squamous cell carcinoma tissues. Its host gene is growth arrest specific transcript 5 (GAS5), which is… read more here.
Keywords: adenovirus expressing; gas5; colorectal cancer; snord44 gas5 ... See more keywords