Delivery Systems for Enhancing Oncolytic Adenoviruses Efficacy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119971
Abstract: Oncolytic adenovirus (OAds) has long been considered a promising biotherapeutic agent against various types of cancer owing to selectively replicate in and lyse cancer cells, while remaining dormant in healthy cells. In the last years,… read more here.
Keywords: adenoviruses efficacy; delivery; delivery systems; enhancing oncolytic ... See more keywords
Locked and loaded: engineering and arming oncolytic adenoviruses to enhance anti-tumor immune responses
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2139601
Abstract: ABSTRACT Introduction Oncolytic adenoviruses (Ads) are promising therapeutics to enhance anti-tumor immune responses and modulate the immune-suppressive tumor microenvironment (TME). Due to their potent ability to deliver genes in vivo, oncolytic Ads have been armed… read more here.
Keywords: anti tumor; immune responses; oncolytic adenoviruses; tumor immune ... See more keywords
54PT-cell therapy: Enabling oncolytic adenoviruses for the treatment of melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx711.035
Abstract: Conclusions Adoptive T cell therapies have shown promising results in clinical trials for solid tumor indications, but efficacy and safety are still suboptimal. We constructed non-replicating and replicating adenoviruses encoding the immunostimulatory cytokines Tumor Necrosis… read more here.
Keywords: cell therapy; therapy enabling; oncolytic adenoviruses; cell ... See more keywords
Novel group C oncolytic adenoviruses carrying a microRNA inhibitor demonstrate enhanced oncolytic activity in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0240
Abstract: Oncolytic adenoviruses (OAds) represent an attractive treatment option for cancer. Clinical efficacy of commonly utilized human Ad type 5 (Ad5) based oncolytic viruses is limited by variable expression levels of the coxsackie- and adenovirus receptor… read more here.
Keywords: oncolytic adenoviruses; enhanced oncolytic; oncolytic activity; tumor ... See more keywords
Oncolytic Adenoviruses in Gastrointestinal Cancers
Sign Up to like & getrecommendations! Published in 2018 at "Biomedicines"
DOI: 10.3390/biomedicines6010033
Abstract: Gastrointestinal malignancies are challenging cancers with considerable economic and societal impacts on health care systems worldwide. While advances in surgical approaches have provided benefits to a proportion of patients, only modest improvements have been attained… read more here.
Keywords: oncolytic adenoviruses; gastrointestinal cancers; adenoviruses gastrointestinal; tumor ... See more keywords
Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic Adenoviruses
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12041034
Abstract: Clinical results with oncolytic adenoviruses (OAds) used as antitumor monotherapies show limited efficacy. To increase OAd potency, transgenes have been inserted into their genome, a strategy known as “arming OAds”. Here, we review different parameters… read more here.
Keywords: transcriptional control; control elements; oncolytic adenoviruses; transgene location ... See more keywords
Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12061504
Abstract: Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense… read more here.
Keywords: improved targeting; adenoviruses strategies; specificity oncolytic; oncolytic adenoviruses ... See more keywords
Complexing the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T with Cationic Nanoparticles Enhances Viral Infection and Spread in Prostate and Pancreatic Cancer Models
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168884
Abstract: Oncolytic adenoviruses (OAd) can be employed to efficiently eliminate cancer cells through multiple mechanisms of action including cell lysis and immune activation. Our OAds, AdΔΔ and Ad-3∆-A20T, selectively infect, replicate in, and kill adenocarcinoma cells… read more here.
Keywords: cell; pancreatic cancer; infection; oncolytic adenoviruses ... See more keywords
Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11101146
Abstract: Cancer is among the major leading causes of mortality globally, and chemotherapy is currently one of the most effective cancer therapies. Unfortunately, chemotherapy is invariably accompanied by dose-dependent cytotoxic side effects. Recently, genetically engineered adenoviruses… read more here.
Keywords: oncolytic adenoviruses; engineered oncolytic; therapy; cancer therapy ... See more keywords
A Renaissance for Oncolytic Adenoviruses?
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15020358
Abstract: In the 1990s, adenovirus became one of the first virus types to be genetically engineered to selectively destroy cancer cells. In the intervening years, the field of “oncolytic viruses” has slowly progressed and culminated in… read more here.
Keywords: renaissance oncolytic; adenovirus; oncolytic adenoviruses; virus ... See more keywords