Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms
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DOI: 10.1038/s41598-025-98588-7
Abstract: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present unique challenges due to their heterogeneity and limited treatment options. Oncolytic virotherapy has emerged as a promising therapeutic for other NETs and thus, we sought to investigate the potential of… read more here.
Keywords: oncolytic herpes; gastroenteropancreatic neuroendocrine; gep nets; herpes simplex ... See more keywords
Oncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery"
DOI: 10.1080/10717544.2018.1534895
Abstract: Abstract Oncolytic herpes simplex viruses (oHSVs) have been approved for clinical usage and become more and more popular for tumor virotherapy. However, there are still many issues for the oHSVs used in clinics and clinical… read more here.
Keywords: engineering; oncolytic herpes; envelope glycoproteins; neutralization ... See more keywords
MODULATING AUTOPHAGY USING ONCOLYTIC HERPES SIMPLEX VIRUSES AND METFORMIN FOR IMMUNOTHERAPY IN GLIOBLASTOMA
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DOI: 10.1093/neuonc/noaf185.030
Abstract: Glioblastoma (GBM) is the most aggressive primary brain tumor, necessitating innovative therapeutic ap- proaches. Although oncolytic herpes simplex viruses (oHSV) are promising therapies, their efficacy as monotherapies is limited. In this context, modulating autophagy—a key… read more here.
Keywords: oncolytic herpes; simplex viruses; glioblastoma; herpes simplex ... See more keywords
Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-008880
Abstract: Background Glioblastoma (GBM), a highly immunosuppressive and often fatal primary brain tumor, lacks effective treatment options. GBMs contain a subpopulation of GBM stem-like cells (GSCs) that play a central role in tumor initiation, progression, and… read more here.
Keywords: oncolytic herpes; herpes simplex; gbm; tumor ... See more keywords
Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1469511
Abstract: Introduction Oncolytic herpes simplex viruses (oHSVs) are a type of biotherapeutic utilized in cancer therapy due to their ability to selectively infect and destroy tumor cells without harming healthy cells. We sought to investigate the… read more here.
Keywords: cells infected; oncolytic herpes; gene expression; analysis ... See more keywords
Proteomic Analysis of Secretomes of Oncolytic Herpes Simplex Virus-Infected Squamous Cell Carcinoma Cells
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DOI: 10.3390/cancers10020028
Abstract: Oncolytic herpes simplex virus type 1 (HSV-1) strain RH2 induced immunogenic cell death (ICD) with the release and surface exposure of damage-associated molecular patterns (DAMPs) in squamous cell carcinoma (SCC) SCCVII cells. The supernatants of… read more here.
Keywords: oncolytic herpes; cell carcinoma; squamous cell; herpes simplex ... See more keywords
Advances in the Drug Development and Quality Evaluation Principles of Oncolytic Herpes Simplex Virus
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DOI: 10.3390/v17040581
Abstract: Oncolytic herpes simplex virus (oHSV) represents a promising therapeutic approach to treating cancers by virtue of its selective replication in and lysis of tumor cells, with stimulation of host antitumor immunity. At present, four OV… read more here.
Keywords: quality; development quality; oncolytic herpes; herpes simplex ... See more keywords
Oncolytic Herpes Simplex Virus Therapy: Latest Advances, Core Challenges, and Future Outlook
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DOI: 10.3390/vaccines13080880
Abstract: Oncolytic virus (OV) immunotherapy, particularly with oncolytic herpes simplex virus (oHSV), has become a promising new strategy in cancer treatment. This field has achieved significant clinical milestones, highlighted by the FDA approval of Talimogene laherparepvec… read more here.
Keywords: oncolytic herpes; therapy; herpes simplex; virus ... See more keywords
Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity
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DOI: 10.3892/ol.2018.9720
Abstract: Liver metastasis represents the most prominent metastasis of colorectal cancer (CRC) and is the leading cause of CRC mortality, making the early prevention of this event very important. While current CRC therapies include surgery, radiotherapy… read more here.
Keywords: oncolytic herpes; colorectal cancer; metastasis; liver metastasis ... See more keywords