Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
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DOI: 10.1136/jitc-2022-006408
Abstract: Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, compromising the amount of… read more here.
Keywords: hsv1; leader; transgene; oncolytic hsv1 ... See more keywords