Oncolytic peptide nanomachine circumvents chemo resistance of renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2022.121488
Abstract: Due to intrinsic and acquired chemo/radiotherapy-resistance, renal cell carcinoma shows limited therapeutic response to clinically utilized targeting drugs. Here a tumor-activated oncolytic peptide nanomachine is devised to selectively lysing tumor cell membrane without causing drug… read more here.
Keywords: oncolytic peptide; resistance; peptide nanomachine; tumor ... See more keywords
Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1338236
Abstract: ABSTRACT LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma… read more here.
Keywords: ltx 315; oncolytic peptide; model; abscopal effect ... See more keywords
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004129
Abstract: Background LTX-315 is an oncolytic peptide deriving from bovine lactoferrin, with the ability to induce cancer immunogenic cell death. However, the mechanism used by LTX-315 to trigger the antitumor immune response is still poorly understood.… read more here.
Keywords: cancer; ltx 315; oncolytic peptide; cancer immunity ... See more keywords
Abstract 4705: The novel oncolytic peptide, DTT-304, induces regression of colorectal cancer tumors in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4705
Abstract: Colorectal cancer (CRC) is the third most common cancer in the world, and approximately 50% of the patients develop liver metastasis, which is a major cause of disease mortality. New drugs and treatment options are… read more here.
Keywords: oncolytic peptide; colorectal cancer; cancer; cell ... See more keywords