Oncolytic reovirus sensitizes multiple myeloma cells to anti-PD-L1 therapy
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/leu.2017.272
Abstract: Adaptive resistance mediated by inhibitory ligands such as PD-L1 has emerged as an important mechanism of malignant cell survival and spurred the development of new agents that disrupt the PD-L1/PD-1 immune checkpoint.1 Analysis of patient… read more here.
Keywords: myeloma; reovirus sensitizes; multiple myeloma; sensitizes multiple ... See more keywords
Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer
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DOI: 10.1158/1078-0432.ccr-20-2385
Abstract: Purpose: To explore the effects of pelareorep on autophagy in multiple models of colorectal cancer, including patient-derived peripheral blood mononuclear cells (PBMCs). Experimental Design: HCT116 [KRAS mutant (mut)] and Hke3 [KRAS wild-type (WT)] cells were… read more here.
Keywords: expression; cancer; oncolytic reovirus; reovirus pelareorep ... See more keywords