Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23677
Abstract: Interleukin 24 (IL‐24) is an IL‐10 family member and a secreted cytokine characterized by cancer‐targeted toxicity and can activate apoptosis by sensitizing cancer cells to chemotherapy. Cytotoxic effects of luteolin on different types of cancer… read more here.
Keywords: liver cancer; oncolytic vaccinia; cancer cells; cancer ... See more keywords
Stereotactic body radiation combined with oncolytic vaccinia virus induces potent anti-tumor effect by triggering tumor cell necroptosis and DAMPs.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.09.040
Abstract: Radiation is an integral part of cancer therapy. With the emergence of oncolytic vaccinia virus immunotherapy, it is important to study the combination of radiation and vaccinia virus in cancer therapy. In this study, we… read more here.
Keywords: anti tumor; oncolytic vaccinia; vaccinia virus; tumor ... See more keywords
Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade
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DOI: 10.1126/scitranslmed.aax7992
Abstract: Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors. A virus with benefits Oncolytic viruses, which kill cancer cells, have received increasing attention in recent years as the field… read more here.
Keywords: checkpoint blockade; immune checkpoint; oncolytic vaccinia; checkpoint ... See more keywords
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-000710
Abstract: Immune checkpoint blockade is arguably the most effective current cancer therapy approach; however, its efficacy is limited to patients with “hot” tumors, warranting an effective approach to transform “cold” tumors. Oncolytic viruses (especially properly armed… read more here.
Keywords: cancer; oncolytic vaccinia; vaccinia virus; tumor ... See more keywords
Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002569
Abstract: Background Viral-based immunotherapy can overcome resistance to immune checkpoint blockade (ICB) and fill the unmet needs of many patients with cancer. Oncolytic viruses (OVs) are defined as engineered or naturally occurring viruses that selectively replicate… read more here.
Keywords: heat; antitumor immunity; vaccinia; oncolytic vaccinia ... See more keywords
Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006024
Abstract: Background Oncolytic virus immunotherapy has revolutionized cancer immunotherapy by efficiently inducing both oncolysis and systemic immune activation. Locoregional administration has been used for oncolytic virus therapy, but its applications to deep-seated cancers have been limited.… read more here.
Keywords: oncolytic vaccinia; vaccinia; vaccinia virus; complement mediated ... See more keywords
Phase I Study of Oncolytic Vaccinia Virus GL-ONC1 in Patients with Peritoneal Carcinomatosis
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DOI: 10.1158/1078-0432.ccr-18-0244
Abstract: Purpose: Peritoneal carcinomatosis is common in advanced tumor stages or disease recurrence arising from gastrointestinal cancers, gynecologic malignancies, or primary peritoneal carcinoma. Because current therapies are mostly ineffective, new therapeutic approaches are needed. Here, we… read more here.
Keywords: peritoneal carcinomatosis; carcinomatosis; oncolytic vaccinia; phase study ... See more keywords
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing
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DOI: 10.1158/1535-7163.mct-20-0863
Abstract: Oncolytic vaccinia viruses have promising efficacy and safety profiles in cancer therapy. Although antitumor activity can be increased by manipulating viral genes, the relative efficacy of individual modifications has been difficult to assess without side-by-side… read more here.
Keywords: expression; antitumor activity; oncolytic vaccinia; gene ... See more keywords
Abstract 1885: Selection of an optimal anti-PD-L1 single domain antibody format for the vectorization into oncolytic vaccinia virus and the generation of bispecific immunomodulators
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1885
Abstract: Background: Single domain antibodies (sdAbs) isolated after immunization of camelids are particularly attractive formats for their high modularity and small size allowing a better diffusion into tumors. However, the short in vivo half-life of sdAbs,… read more here.
Keywords: oncolytic vaccinia; sdab; domain; activity ... See more keywords
Abstract PR19: Utilizing novel oncolytic vaccinia virus for selective expression of immunotherapeutic payloads in metastatic tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-pr19
Abstract: The treatment paradigm for patients with metastatic cancer has evolved rapidly with the approval of agents targeting CTLA-4 and the PD-1/L1 immune checkpoint axis. Despite the profound impact these agents have had, they are minimally… read more here.
Keywords: expression; oncolytic vaccinia; immunology; virus ... See more keywords
Oncolytic Vaccinia Virus Augments T Cell Factor 1-Positive Stem-like CD8+ T Cells, Which Underlies the Efficacy of Anti-PD-1 Combination Immunotherapy
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DOI: 10.3390/biomedicines10040805
Abstract: Oncolytic virotherapy has garnered attention as an antigen-agnostic therapeutic cancer vaccine that induces cancer-specific T cell responses without additional antigen loading. As anticancer immune responses are compromised by a lack of antigenicity and chronic immunosuppressive… read more here.
Keywords: oncolytic vaccinia; mjx 594; vaccinia virus; cd8 cells ... See more keywords