STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0527-7
Abstract: Cancer-associated fibroblasts (CAFs) perform diverse roles and can modulate therapy responses 1 . The inflammatory environment within tumours also influences responses to many therapies, including the efficacy of oncolytic viruses 2 ; however, the role… read more here.
Keywords: therapy; sting irf3; oncolytic viral; cancer cells ... See more keywords
Talimogene Laherparepvec (T-VEC): Expanding Horizons in Oncolytic Viral Therapy Across Multiple Cancer Types.
Sign Up to like & getrecommendations! Published in 2025 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/0118715206379105250429115604
Abstract: Talimogene laherparepvec (T-VEC), the first FDA-approved oncolytic viral therapy, has transformed cancer immunotherapy since its 2015 approval for unresectable melanoma. Engineered from Herpes Simplex Virus type 1 (HSV-1) with deletions in ICP34.5 and ICP47 genes… read more here.
Keywords: cancer; laherparepvec vec; therapy; oncolytic viral ... See more keywords
Oncolytic viral therapy as a novel potential solution for treatment of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2025 at "Gastroenterology and Hepatology From Bed to Bench"
DOI: 10.22037/ghfbb.v18i1.3066
Abstract: Pancreatic cancer (PC) remains one of the most formidable malignancies, with survival rates showing minimal improvement over the years despite progress in chemotherapy, targeted treatments, and radiation therapy. The development of targeted agents and chemotherapy… read more here.
Keywords: cancer; treatment; therapy; oncolytic viral ... See more keywords
Targeting Cancers with oHSV-Based Oncolytic Viral Immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb46060334
Abstract: The recent success of cancer immunotherapies, such as immune checkpoint inhibitor (ICIs), monoclonal antibodies (mAbs), cancer vaccines, and adoptive cellular therapies (ACTs), has revolutionized traditional cancer treatment. However, these immunotherapeutic modalities have variable efficacies, and… read more here.
Keywords: cancer; immunotherapy; oncolytic viral; viral immunotherapy ... See more keywords