Oncolytic Virotherapy by HSV.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-7230-7_4
Abstract: Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type… read more here.
Keywords: generation oncolytic; virotherapy hsv; virotherapy; oncolytic viruses ... See more keywords
Comprehensive characterization of tumor immune landscape following oncolytic virotherapy by single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-03084-2
Abstract: An important mechanism of oncolytic virotherapy in ameliorating cancer immunotherapy is by inducing significant changes in the immune landscape in the tumor microenvironment (TME). Despite this notion and the potential therapeutic implications, a comprehensive analysis… read more here.
Keywords: immune landscape; single cell; oncolytic virotherapy; virotherapy ... See more keywords
α2,6-linked sialic acid serves as a high-affinity receptor for cancer oncolytic virotherapy with Newcastle disease virus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-017-2470-y
Abstract: PurposeNewcastle disease virus (NDV) has been applied to oncolytic virotherapy for decades due to its naturally oncolytic property. In spite of the substantiation of the sialic acid receptors of NDV on host cells, knowledge of… read more here.
Keywords: receptor; oncolytic virotherapy; sialic acid; affinity ... See more keywords
A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Mathematical Chemistry"
DOI: 10.1007/s10910-019-01084-3
Abstract: In this paper, we propose a mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative to treatment of a glioma. The main idea is to incorporate the virotherapy after the first or second… read more here.
Keywords: oncolytic virotherapy; combines chemotherapy; chemotherapy oncolytic; virotherapy ... See more keywords
Natural Killer Cells Recruitment in Oncolytic Virotherapy: A Mathematical Model.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of mathematical biology"
DOI: 10.1007/s11538-021-00903-6
Abstract: In this paper, we investigate how natural killer (NK) cell recruitment to the tumor microenvironment (TME) affects oncolytic virotherapy. NK cells play a major role against viral infections. They are, however, known to induce early… read more here.
Keywords: natural killer; mathematical model; oncolytic virotherapy; virotherapy ... See more keywords
Anti-viral Immunity in the Tumor Microenvironment: Implications for the Rational Design of Herpes Simplex Virus Type 1 Oncolytic Virotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Current Clinical Microbiology Reports"
DOI: 10.1007/s40588-019-00134-3
Abstract: The design of novel herpes simplex type I (HSV-1)–derived oncolytic virotherapies is a balancing act between safety, immunogenicity, and replicative potential. We have undertaken this review to better understand how these considerations can be incorporated… read more here.
Keywords: anti viral; tumor; herpes simplex; tumor microenvironment ... See more keywords
Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.07.035
Abstract: Antoni Ribas,* Reinhard Dummer, Igor Puzanov, Ari VanderWalde, Robert H.I. Andtbacka, Olivier Michielin, Anthony J. Olszanski, Josep Malvehy, Jonathan Cebon, Eugenio Fernandez, John M. Kirkwood, Thomas F. Gajewski, Lisa Chen, Kevin S. Gorski, AbrahamA. Anderson,… read more here.
Keywords: promotes intratumoral; virotherapy promotes; cell infiltration; intratumoral cell ... See more keywords
Histone deacetylase inhibitor-based oncolytic virotherapy: a promising strategy for cancer treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discovery today"
DOI: 10.1016/j.drudis.2022.02.009
Abstract: A significant impediment to the treatment of solid and nonsolid cancers is the decline of drug efficacy and/or occurrence of adverse effects. In recent years, there has been increasing interest in oncolytic viruses (OVs) as… read more here.
Keywords: cancer; histone deacetylase; treatment; oncolytic virotherapy ... See more keywords
Boundedness in a haptotactic cross-diffusion system modeling oncolytic virotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Differential Equations"
DOI: 10.1016/j.jde.2020.07.032
Abstract: Abstract This paper is concerned with a haptotactic cross-diffusion system as the model for oncolytic virotherapy, which describes the influence of the extracellular matrix (ECM) taxis over the tumor-oncolytic virus interaction in the form of… read more here.
Keywords: system; diffusion system; oncolytic virotherapy; haptotactic cross ... See more keywords
Backward Hopf bifurcation in a mathematical model for oncolytic virotherapy with the infection delay and innate immune effects
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biological Dynamics"
DOI: 10.1080/17513758.2019.1667443
Abstract: In this paper, we consider a system of delay differential equations that models the oncolytic virotherapy on solid tumours with the delay of viral infection in the presence of the innate immune response. We conduct… read more here.
Keywords: infection; delay; backward hopf; hopf bifurcation ... See more keywords
Transforming the prostatic tumor microenvironment with oncolytic virotherapy
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1445459
Abstract: ABSTRACT Prostate cancer (PCa) was estimated to have the second highest global incidence rate for male non-skin tumors and is the fifth most deadly in men thus mandating the need for novel treatment options. MG1-Maraba… read more here.
Keywords: microenvironment oncolytic; transforming prostatic; tumor microenvironment; oncolytic virotherapy ... See more keywords