Oncolytic virus preclinical toxicology studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4408
Abstract: With the ever‐emerging concerns of patient safety during medical care, the search for treatments as safe as possible is a priority, especially when focusing on cancer treatment of which therapies often go hand in hand… read more here.
Keywords: toxicology; oncolytic virus; preclinical toxicology; studies oncolytic ... See more keywords
Application of oncolytic virus in tumor therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28729
Abstract: Oncolytic viruses (OVs) can selectively kill tumor cells without affecting normal cells, as well as activate the innate and adaptive immune systems in patients. Thus, they have been considered as a promising measure for safe… read more here.
Keywords: oncolytic virus; tumor therapy; therapy; application oncolytic ... See more keywords
Engineered oncolytic virus for the treatment of cholesteatoma: A pilot in vivo study
Sign Up to like & getrecommendations! Published in 2019 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.307
Abstract: Determine if oncolytic herpes simplex virus (oHSV) can eradicate cholesteatoma (CHST) in a gerbil model. read more here.
Keywords: oncolytic virus; cholesteatoma; treatment cholesteatoma; virus treatment ... See more keywords
Oncolytic Virus-Driven Biotherapies from Bench to Bedside.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202206948
Abstract: With advances in cancer biology and an ever-deepening understanding of molecular virology, oncolytic virus (OV)-driven therapies have developed rapidly and become a promising alternative to traditional cancer therapies. In recent years, satisfactory results for oncolytic… read more here.
Keywords: ovt delivery; oncolytic virus; driven biotherapies; virus driven ... See more keywords
Oncolytic virus combined with traditional treatment versus traditional treatment alone in patients with cancer: a meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-020-01760-4
Abstract: Oncolytic virus therapy has shown benefits for multiple cancers, while limitations remain for traditional treatment. However, few studies have concentrated on comparing whether oncolytic virus combined with traditional treatment is better than traditional treatment alone… read more here.
Keywords: oncolytic virus; treatment; traditional treatment; treatment alone ... See more keywords
Newcastle disease virus strain AF2240 as an oncolytic virus: A review.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.04.007
Abstract: The discovery of tumour selective virus-mediated apoptosis marked the birth of an alternative cancer treatment in the form of oncolytic viruses. Even though, its oncolytic efficiency was demonstrated more than 50 years ago, safety concerns… read more here.
Keywords: disease virus; oncolytic virus; strain af2240; strain ... See more keywords
A generic viral dynamic model to systematically characterize the interaction between oncolytic virus kinetics and tumor growth
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.11.003
Abstract: &NA; Oncolytic viruses (OV) represent an encouraging new therapeutic concept for treatment of human cancers. OVs specifically replicate in tumor cells and initiate cell lysis whilst tumor cells act as endogenous bioreactors for virus amplification.… read more here.
Keywords: oncolytic virus; viral dynamic; dynamic model; growth ... See more keywords
Targeting matrix metalloproteinase MMP3 greatly enhances oncolytic virus mediated tumor therapy
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101221
Abstract: Highlights • MMP3 is upregulated in colon cancers.• Tumor cell-associated MMP3 expression is important for tumor growth.• The cancer therapy by MMP3 inhibition is improved together with oncolytic virus.• Downregulation of MMP3 reduces tumor cell… read more here.
Keywords: oncolytic virus; mmp3; therapy; targeting matrix ... See more keywords
Section 4: Immunopharmacology
Sign Up to like & getrecommendations! Published in 2017 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.67
Abstract: Doi: 10.1038/aps.2017.67 S4.1 Naturally existing oncolytic virus M1 is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injections Hai-peng ZHANG, Yuan LIN, Kai LI, Jian-kai LIANG, Xiao XIAO, Guang-mei YAN, Yuan LIN… read more here.
Keywords: administration; oncolytic virus; cynomolgus macaques; section immunopharmacology ... See more keywords
THER-01. AWAKING THE IMMUNE SYSTEM WITH AN IMMUNO-ONCOLYTIC VIRUS AS A THERAPEUTIC STRATEGY FOR DIPGs
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.851
Abstract: Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumour, being the leading cause of paediatric death caused by cancer. Despite all the advances made regarding effective therapies, the survival is dismal. Our lab… read more here.
Keywords: dipg; delta act; act; oncolytic virus ... See more keywords
Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam7996
Abstract: Inhibition of VCP sensitizes hepatocellular carcinoma cells to oncolytic virus M1–induced apoptosis. A virus and its reinforcement Oncolytic viruses can be effective against a variety of cancers, including hepatocellular carcinoma, where a viral treatment is… read more here.
Keywords: hepatocellular carcinoma; oncolytic virus; activity; efficacy ... See more keywords