Oncolytic Virotherapy by HSV.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-7230-7_4
Abstract: Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type… read more here.
Keywords: generation oncolytic; virotherapy hsv; virotherapy; oncolytic viruses ... See more keywords
The application of oncolytic viruses in cancer therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology letters"
DOI: 10.1007/s10529-021-03173-3
Abstract: Oncolytic therapy is a treatment method used to directly combat tumor cells by modifying the genes of naturally occurring low pathogenic viruses to form "rhizobia" virus. By taking the advantage of abnormal signal pathways in… read more here.
Keywords: viruses cancer; application oncolytic; oncolytic viruses; therapy ... See more keywords
Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas.
Sign Up to like & getrecommendations! Published in 2017 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.02.002
Abstract: Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability… read more here.
Keywords: mesenchymal stromal; cells delivery; stromal cells; viruses gliomas ... See more keywords
Probing effects of additives on the filterability of oncolytic viruses via a microfiltration process
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Membrane Science"
DOI: 10.1016/j.memsci.2020.118783
Abstract: Abstract One major part of therapeutic oncolytic viruses (OV) manufacturing is a membrane-based process with a major challenge of membrane fouling and consequent product loss. A small-scale microfiltration setup was developed, allowing online transmembrane pressure… read more here.
Keywords: additives filterability; process; oncolytic viruses; probing effects ... See more keywords
Boarding Oncolytic Viruses onto Tumor-Homing Bacterium-Vessels for Augmented Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00699
Abstract: Oncolytic viruses (OVs) have been widely used as anticancer therapeutics because of their systemic immune responses during viral replication. However, the low enrichment of OVs within tumors and limited immune activation have hindered their clinical… read more here.
Keywords: tumor homing; onto tumor; oas; oncolytic viruses ... See more keywords
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00951-x
Abstract: Oncolytic viruses (OVs) are emerging as potentially useful platforms in treatment methods for patients with tumors. They preferentially target and kill tumor cells, leaving healthy cells unharmed. In addition to direct oncolysis, the essential and… read more here.
Keywords: engineering strategies; cancer; viruses cancer; oncolytic viruses ... See more keywords
Oncolytic Viruses for Tumor Precision Imaging and Radiotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Human gene therapy"
DOI: 10.1089/hum.2017.189
Abstract: In 2003 in China, Peng et al. invented the recombinant adenovirus expressing p53 (Gendicine) for clinical tumor virotherapy. This was the first clinically approved gene therapy and tumor virotherapy drug in the world. An oncolytic… read more here.
Keywords: tumor precision; imaging radiotherapy; oncolytic viruses;
Chorioallantoic Membrane Tumor Model for Evaluating Oncolytic Viruses
Sign Up to like & getrecommendations! Published in 2020 at "Human Gene Therapy"
DOI: 10.1089/hum.2020.045
Abstract: Oncolytic viruses are promising anticancer agents; however, regarding their clinical efficacy, there is still significant scope for improvement. Preclinical in vivo evaluation of oncolytic viruses is mainly based on syngeneic or xenograft tumor models in… read more here.
Keywords: membrane tumor; tumor model; chorioallantoic membrane; model ... See more keywords
Generation of Genetically RGD σ1-Modified Oncolytic Reovirus That Enhances JAM-A-Independent Infection of Tumor Cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01703-20
Abstract: Oncolytic viruses kill tumors without affecting normal cells. A variety of oncolytic viruses are used as cancer therapeutics. Mammalian reovirus (MRV), which belongs to the genus Orthoreovirus, family Reoviridae, is one such natural oncolytic virus.… read more here.
Keywords: modified oncolytic; cancer; jam; oncolytic viruses ... See more keywords
Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004167
Abstract: Tumor cells manipulate the local environment in which they grow, creating a tumor microenvironment (TME) that promotes tumor survival and metastasis. The TME is an extremely complex environment rich in immunosuppressive cells and cytokines. Various… read more here.
Keywords: tumor; tumor cells; tumor microenvironment; oncolytic viruses ... See more keywords
Abstract 6417: Deciphering aberrant STING pathway and exploring oncolytic viruses therapy in low grade serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6417
Abstract: There are two serous ovarian cancer histotypes, low and high grade (LGSOC and HGSOC), which are distinct clinical and biological entities. LGSOC is a rare histotype with a relatively stable genome, while HGSC is more… read more here.
Keywords: aberrant sting; sting pathway; serous ovarian; oncolytic viruses ... See more keywords