Development of a Generic Physiologically Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2530
Abstract: Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting. There is limited information in humans regarding safety of ondansetron exposure to nursing infants and no adequate study looking at ondansetron pharmacokinetics during… read more here.
Keywords: exposure; ondansetron; model; breast milk ... See more keywords
The role of ondansetron in prevention of post-spinal shivering (PSS) in obstetric patients: A double-blind randomized controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "Egyptian Journal of Anaesthesia"
DOI: 10.1016/j.egja.2016.12.004
Abstract: Abstract Background Elective cesarean delivery (C/D) under neuraxial anesthesia is commonly associated with shivering. Ondansetron is a widely used antiemetic during both pregnancy and surgery. Few controversial studies investigated its anti-shivering effect in C/D under… read more here.
Keywords: spinal shivering; post spinal; group; ondansetron ... See more keywords
Anti-dyskinetic efficacy of 5-HT3 receptor antagonist in the hemi-parkinsonian rat model
Sign Up to like & getrecommendations! Published in 2019 at "IBRO Reports"
DOI: 10.1016/j.ibror.2018.12.001
Abstract: Parkinson's disease is a progressive debilitative neurodegenerative disease characterised mostly with bradykinesia, tremor, catatonia, drooping posture, unsteady gate and unstable steps. Levodopa has been proven to be among the most effective and acceptable treatment that… read more here.
Keywords: ondansetron; disease; anti dyskinetic; test ... See more keywords
Publishing negative findings and the challenge of avoiding type II errors in studies of suspect teratogens: Example of a recent ondansetron publication.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2016.12.001
Abstract: It is important that negative, as well as positive, studies be published to complete the available picture in areas of scientific inquiry. At the same time, it is critical that the implications of a negative… read more here.
Keywords: challenge avoiding; avoiding type; ondansetron; negative findings ... See more keywords
Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.08.018
Abstract: The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. Some human epidemiological studies have associated ondansetron with fetal cardiovascular defects and orofacial clefts. This study… read more here.
Keywords: mediated via; herg; ondansetron; ondansetron teratogenicity ... See more keywords
A Comparison of Fosaprepitant and Ondansetron for Preventing Postoperative Nausea and Vomiting in Moderate to High Risk Patients: A Retrospective Database Analysis
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/5703528
Abstract: Postoperative nausea and vomiting (PONV) occur in 30–50% of patients undergoing general anesthesia and in 70–80% of high PONV risk patients. In this study, we investigated the efficacy of fosaprepitant, a neurokinin-1 (NK1) receptor antagonist,… read more here.
Keywords: risk; ondansetron; risk patients; moderate high ... See more keywords
Design and Characterization of Agarose/HPMC Buccal Films Bearing Ondansetron HCl In Vitro and In Vivo: Enhancement Using Iontophoretic and Chemical Approaches
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DOI: 10.1155/2022/1662194
Abstract: The study was aimed at designing and characterizing the ondansetron hydrochloride (OND) bearing agarose (AG), and hydroxypropyl methyl cellulose (HPMC) mucoadhesive buccal films employing glycerol as a plasticizer. The buccal delivery of ondansetron hydrochloride was… read more here.
Keywords: vivo; buccal films; enhancement; ondansetron ... See more keywords
Kidney and Mortality Outcomes Associated with Ondansetron in Critically Ill Patients
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DOI: 10.1177/08850666211073582
Abstract: Background: Ondansetron is a preferred anti-emetic in critical care to treat nausea and vomiting, and has historically been considered a largely safe option. A recent pharmacoepidemiology study reported that ondansetron may be associated with an… read more here.
Keywords: aki; intensive care; ondansetron; mortality ... See more keywords
Assessment of absorption of transdermal ondansetron in normal research cats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x16688807
Abstract: Objectives The objective of this study was to assess the absorption of transdermal ondansetron in healthy cats. Methods Five research cats with unremarkable complete blood count, biochemistry and urinalysis were used for both single- and… read more here.
Keywords: absorption transdermal; transdermal ondansetron; ondansetron; research cats ... See more keywords
Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
Sign Up to like & getrecommendations! Published in 2022 at "Pakistan Journal of Medical Sciences"
DOI: 10.12669/pjms.38.7.5585
Abstract: Objectives: To evaluate and compare the Ondansetron and Granisetron in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients Methods: The comparative analytical study was conducted at Combined Military Hospital, Rawalpindi, from September to October,… read more here.
Keywords: group; ondansetron; spinal anaesthesia; value ... See more keywords
Comparison of ramosetron and ondansetron for the treatment of established postoperative nausea and vomiting after laparoscopic surgery: a prospective, randomized, double-blinded multicenter trial
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutics and Clinical Risk Management"
DOI: 10.2147/tcrm.s159211
Abstract: Background Postoperative nausea and vomiting (PONV) is a common complication after surgery, which increases physical and psychological discomfort and delays recovery. The aim of this study was to test the hypothesis that ramosetron is comparable… read more here.
Keywords: surgery; ondansetron; laparoscopic surgery; nausea ... See more keywords