Development of a Generic Physiologically Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2530
Abstract: Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting. There is limited information in humans regarding safety of ondansetron exposure to nursing infants and no adequate study looking at ondansetron pharmacokinetics during… read more here.
Keywords: exposure; ondansetron; model; breast milk ... See more keywords
The role of ondansetron in prevention of post-spinal shivering (PSS) in obstetric patients: A double-blind randomized controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "Egyptian Journal of Anaesthesia"
DOI: 10.1016/j.egja.2016.12.004
Abstract: Abstract Background Elective cesarean delivery (C/D) under neuraxial anesthesia is commonly associated with shivering. Ondansetron is a widely used antiemetic during both pregnancy and surgery. Few controversial studies investigated its anti-shivering effect in C/D under… read more here.
Keywords: spinal shivering; post spinal; group; ondansetron ... See more keywords
Anti-dyskinetic efficacy of 5-HT3 receptor antagonist in the hemi-parkinsonian rat model
Sign Up to like & getrecommendations! Published in 2019 at "IBRO Reports"
DOI: 10.1016/j.ibror.2018.12.001
Abstract: Parkinson's disease is a progressive debilitative neurodegenerative disease characterised mostly with bradykinesia, tremor, catatonia, drooping posture, unsteady gate and unstable steps. Levodopa has been proven to be among the most effective and acceptable treatment that… read more here.
Keywords: ondansetron; disease; anti dyskinetic; test ... See more keywords
Publishing negative findings and the challenge of avoiding type II errors in studies of suspect teratogens: Example of a recent ondansetron publication.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2016.12.001
Abstract: It is important that negative, as well as positive, studies be published to complete the available picture in areas of scientific inquiry. At the same time, it is critical that the implications of a negative… read more here.
Keywords: challenge avoiding; avoiding type; ondansetron; negative findings ... See more keywords
Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.08.018
Abstract: The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. Some human epidemiological studies have associated ondansetron with fetal cardiovascular defects and orofacial clefts. This study… read more here.
Keywords: mediated via; herg; ondansetron; ondansetron teratogenicity ... See more keywords
A real-world safety signal detection study of ondansetron based on FAERS reports from 2014 to 2024
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-16384-9
Abstract: Ondansetron is widely acknowledged for its effectiveness in preventing and treating postoperative nausea and vomiting. Nevertheless, comprehensive research on its adverse effects is still limited. This study intends to explore the adverse events (AEs) related… read more here.
Keywords: 2014 2024; ror; analysis; ondansetron ... See more keywords
Signal mining of adverse reactions in the antiemetic drug ondansetron during pregnancy:A Real-World analysis of the FDA adverse Event Reporting System (FAERS).
Sign Up to like & getrecommendations! Published in 2024 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2024.2386684
Abstract: BACKGROUND The aim of this study is to assess the risks associated with the use of ondansetron in pregnant women in real-world based on the Food and Drug Administration adverse Event Reporting System (FAERS). METHODS… read more here.
Keywords: system; adverse reactions; ondansetron; real world ... See more keywords
Bioavailability of Oral Ondansetron in Dogs: A Crossover Study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.70024
Abstract: The purpose of this study was to evaluate the pharmacokinetics of oral (PO) ondansetron compared to intravenous (IV) ondansetron in eight healthy client‐owned dogs. Dogs were randomized to one of two protocols in a crossover… read more here.
Keywords: dogs crossover; ondansetron; oral ondansetron; ondansetron dogs ... See more keywords
A Comparison of Fosaprepitant and Ondansetron for Preventing Postoperative Nausea and Vomiting in Moderate to High Risk Patients: A Retrospective Database Analysis
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/5703528
Abstract: Postoperative nausea and vomiting (PONV) occur in 30–50% of patients undergoing general anesthesia and in 70–80% of high PONV risk patients. In this study, we investigated the efficacy of fosaprepitant, a neurokinin-1 (NK1) receptor antagonist,… read more here.
Keywords: risk; ondansetron; risk patients; moderate high ... See more keywords
Design and Characterization of Agarose/HPMC Buccal Films Bearing Ondansetron HCl In Vitro and In Vivo: Enhancement Using Iontophoretic and Chemical Approaches
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1662194
Abstract: The study was aimed at designing and characterizing the ondansetron hydrochloride (OND) bearing agarose (AG), and hydroxypropyl methyl cellulose (HPMC) mucoadhesive buccal films employing glycerol as a plasticizer. The buccal delivery of ondansetron hydrochloride was… read more here.
Keywords: vivo; buccal films; enhancement; ondansetron ... See more keywords
Kidney and Mortality Outcomes Associated with Ondansetron in Critically Ill Patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Intensive Care Medicine"
DOI: 10.1177/08850666211073582
Abstract: Background: Ondansetron is a preferred anti-emetic in critical care to treat nausea and vomiting, and has historically been considered a largely safe option. A recent pharmacoepidemiology study reported that ondansetron may be associated with an… read more here.
Keywords: aki; intensive care; ondansetron; mortality ... See more keywords