Pyrrole‐Thiazolidin‐4‐one Analogues Exhibit Promising Anti‐Tuberculosis Activity
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400054
Abstract: A series of pyrrole‐thiazolidin‐4‐one conjugates were synthesized and evaluated for their anti‐mycobacterial and anti‐bacterial activities. Two compounds, 10a and 10k were the most effective conjugates and produced identical MICs (0.5 µg/mL) against M. tuberculosis H37Rv… read more here.
Keywords: pyrrole thiazolidin; tuberculosis; one analogues; analogues exhibit ... See more keywords
8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113697
Abstract: β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a… read more here.
Keywords: design synthesis; potential agonists; agonists design; hydroxyquinolin one ... See more keywords