Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104553
Abstract: A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC50 = 17.7 μM)which was comparable with sorafenib (IC50 = 17.3 μM). There… read more here.
Keywords: agents bearing; based agents; one based; quinazolin one ... See more keywords
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.1c00633
Abstract: Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) with the support of molecular docking studies. The target dicationic or monocationic compounds, which show the guanidium group at different… read more here.
Keywords: one based; guanidine; pyridazin one; minor groove ... See more keywords
Synthesis of 3-oxoesters and functional derivatives of pyrimidin-4(3Н)-one based on 1-(2,6-dihalophenyl)cyclopropan-1-carboxylic acids
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217020128
Abstract: Special features of the synthesis and chemical transformations of novel functional derivatives of 6-[1-(2,6-dihalophenyl)cyclopropyl]pyrimidin-4(3H)-one and ethyl esters of 3-[1-(2,6-dihalophenyl)cyclopropyl]-2-methyl-3-oxopropanoic acids prepared from 2-(2,6-dihalophenyl)acetonitriles have been revealed. Novel achiral structural analogs of experimental anti-HIV agent МС-1501… read more here.
Keywords: functional derivatives; synthesis oxoesters; pyrimidin one; oxoesters functional ... See more keywords
Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0160
Abstract: Aim: Hypertension is a major health problem worldwide resulting in high death rates due to its consequences and complications. Therefore, searching for new vasorelaxants is a must to find new vasodilators efficient for the treatment… read more here.
Keywords: synthesis vasodilator; one based; vasodilator activity; activity ... See more keywords