Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1407
Abstract: Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment. A… read more here.
Keywords: folate mediated; mediated one; metabolism; related genes ... See more keywords
Supplemental one‐carbon metabolism related B vitamins and lung cancer risk in the Women's Health Initiative
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DOI: 10.1002/ijc.32913
Abstract: We and others have reported associations between B vitamins principally involved in one‐carbon metabolism and increased lung cancer risk; however, results for women have been inconsistent. Here we report on the association of supplemental vitamins… read more here.
Keywords: cancer; cancer risk; one carbon; lung cancer ... See more keywords
Development of a Standardized MRM Method for the Quantification of One Carbon Metabolism Enzymes.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1936-0_13
Abstract: One-carbon metabolism (1CM) plays a central role in liver physiology, being the source of essential metabolites such as S-adenosylmethionine, the main alkylating agent in living cells, and glutathione, their most important nonenzymatic antioxidant defense. Impairment… read more here.
Keywords: standardized mrm; carbon metabolism; development standardized; one carbon ... See more keywords
Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model.
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DOI: 10.1016/j.biochi.2018.07.007
Abstract: One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected… read more here.
Keywords: pregnancy; one carbon; carbon metabolism; affect one ... See more keywords
One carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects?
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.02.005
Abstract: Neural tube defects (NTDs) are a broad class of congenital birth defects that result from the failure of neural tube closure during neurulation. Folic acid supplementation has been shown to prevent the occurrence of NTDs… read more here.
Keywords: tube defects; neural tube; one carbon; etiology ... See more keywords
The emerging role of one-carbon metabolism in T cells.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.12.001
Abstract: One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding… read more here.
Keywords: one carbon; carbon metabolism; emerging role;
One-carbon metabolism and epigenetics.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2016.11.007
Abstract: The function of one-carbon metabolism is that of regulating the provision of methyl groups for biological methylation reactions including that of DNA and histone proteins. Methylation at specific sites into the DNA sequence and at… read more here.
Keywords: methylation; carbon; metabolism epigenetics; one carbon ... See more keywords
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.06.039
Abstract: Activated macrophages adapt their metabolic pathways to drive the pro-inflammatory phenotype, but little is known about the biochemical underpinnings of this process. Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine… read more here.
Keywords: metabolism; one carbon; inflammatory macrophages; carbon metabolism ... See more keywords
Fetal one-carbon nutrient concentrations may be affected by gestational diabetes.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition research"
DOI: 10.1016/j.nutres.2018.04.010
Abstract: Both insufficiency and excess of one-carbon nutrients (folate, choline, vitamins B6 and B12) during pregnancy have been associated with gestational diabetes mellitus (GDM). However, the precise nature of this association has not been clearly established.… read more here.
Keywords: iqr; gestational diabetes; carbon; blood ... See more keywords
New Horizons in Acetogenic Conversion of One-Carbon Substrates and Biological Hydrogen Storage.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2019.05.008
Abstract: Strictly anaerobic, acetogenic (acetate-forming) bacteria are characterized by a reductive pathway in which two mol of CO2 are reduced to one mol of acetyl coenzyme A (acetyl-CoA) and then further to acetate, ethanol, or butyrate.… read more here.
Keywords: one carbon; storage; hydrogen storage; carbon substrates ... See more keywords
Reductive Glycine Pathway: A Versatile Route for One-Carbon Biotech.
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DOI: 10.1016/j.tibtech.2021.02.005
Abstract: Hong et al. heterologously expressed the metabolic core of the reductive glycine pathway (rGlyP) as a sink for the anaerobic conversion of glycerol. This recent study concludes several reports in 2020 on the ATP-efficient, one-carbon-assimilating,… read more here.
Keywords: one carbon; glycine pathway; reductive glycine; carbon ... See more keywords